Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 989042..989562 Replicon chromosome
Accession NZ_CP043641
Organism Leifsonia shinshuensis strain INR9

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag F1C12_RS04775 Protein ID WP_185277668.1
Coordinates 989042..989332 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag F1C12_RS04780 Protein ID WP_185277669.1
Coordinates 989329..989562 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1C12_RS04755 984218..985279 - 1062 WP_185278785.1 branched-chain amino acid ABC transporter permease -
F1C12_RS04760 985375..986385 - 1011 WP_185277666.1 branched-chain amino acid ABC transporter permease -
F1C12_RS04765 986510..987730 - 1221 WP_185277667.1 branched-chain amino acid ABC transporter substrate-binding protein -
F1C12_RS04770 987793..989028 + 1236 WP_185278786.1 GNAT family N-acetyltransferase -
F1C12_RS04775 989042..989332 - 291 WP_185277668.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F1C12_RS04780 989329..989562 - 234 WP_185277669.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
F1C12_RS04785 989696..990166 - 471 WP_185277670.1 DUF2867 domain-containing protein -
F1C12_RS04790 990575..991060 + 486 WP_185277671.1 SRPBCC family protein -
F1C12_RS04795 991253..992176 - 924 WP_185277672.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -
F1C12_RS04800 992154..992867 - 714 WP_185277673.1 ribonuclease III -
F1C12_RS04805 992922..993125 - 204 WP_055919953.1 50S ribosomal protein L32 -
F1C12_RS04810 993128..993652 - 525 WP_185278787.1 DUF177 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11124.50 Da        Isoelectric Point: 8.0550

>T139174 WP_185277668.1 NZ_CP043641:c989332-989042 [Leifsonia shinshuensis]
VTRFRFTPAARRDLSSIWDFTQETSDVRQAETYVTEIRAAIERIAADPERGRACDDIRTGYRRYAIGSHLLFYVANGDGV
DVIRILHQRMDPTRHL

Download         Length: 291 bp

>T139174 NZ_CP043641:c989332-989042 [Leifsonia shinshuensis]
GTGACCCGGTTCCGGTTCACTCCGGCCGCGCGGCGCGATCTCTCCTCGATCTGGGACTTCACACAGGAGACCTCGGATGT
GCGTCAGGCCGAGACGTATGTGACCGAGATCCGCGCGGCCATCGAGCGCATTGCGGCTGACCCGGAACGCGGGCGCGCCT
GTGACGACATTCGGACCGGCTACCGGCGTTACGCGATCGGGAGCCATCTGCTCTTCTACGTCGCGAACGGCGACGGTGTC
GATGTCATTCGCATCCTGCATCAGCGGATGGATCCGACCAGGCACCTGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8306.26 Da        Isoelectric Point: 4.3988

>AT139174 WP_185277669.1 NZ_CP043641:c989562-989329 [Leifsonia shinshuensis]
MAMNTSISLDDHFAGFLAHEVATGRYRSASEVVRAGLRLLEDQETQMSALRAALVAGEESGEPEAFDFDAFIAAKKS

Download         Length: 234 bp

>AT139174 NZ_CP058548:c1234884-1234618 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References