Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 4915836..4916368 Replicon chromosome
Accession NZ_CP043638
Organism Streptomyces sp. INR7

Toxin (Protein)


Gene name relE Uniprot ID A0A3R9VSQ2
Locus tag F1D59_RS21955 Protein ID WP_030662809.1
Coordinates 4915836..4916099 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0M8UN66
Locus tag F1D59_RS21960 Protein ID WP_030662806.1
Coordinates 4916096..4916368 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1D59_RS21925 4911410..4911601 - 192 WP_030662818.1 hypothetical protein -
F1D59_RS21930 4911840..4912529 + 690 WP_030011324.1 cell division ATP-binding protein FtsE -
F1D59_RS21935 4912546..4913505 + 960 WP_053625584.1 permease-like cell division protein FtsX -
F1D59_RS21940 4913573..4914751 + 1179 WP_053684032.1 PDZ domain-containing protein -
F1D59_RS21945 4914770..4915255 + 486 WP_030028291.1 SsrA-binding protein SmpB -
F1D59_RS21955 4915836..4916099 - 264 WP_030662809.1 Txe/YoeB family addiction module toxin Toxin
F1D59_RS21960 4916096..4916368 - 273 WP_030662806.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F1D59_RS21965 4916513..4917658 - 1146 WP_185558462.1 SH3 domain-containing protein -
F1D59_RS21970 4917708..4918835 - 1128 WP_107087198.1 MFS transporter -
F1D59_RS21975 4919118..4920104 + 987 WP_053612943.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-71)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10390.82 Da        Isoelectric Point: 9.4377

>T139172 WP_030662809.1 NZ_CP043638:c4916099-4915836 [Streptomyces sp. INR7]
VRSVHFDPDAWEDFLFWLGADRKMAKRITRLIQEIQRSPFAGIGKPEPLKGDLTGYWSRRIDDEHRLVYRADDKEVKILK
ARYHYSD

Download         Length: 264 bp

>T139172 NZ_CP058546:c172538-172068 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9879.10 Da        Isoelectric Point: 4.4978

>AT139172 WP_030662806.1 NZ_CP043638:c4916368-4916096 [Streptomyces sp. INR7]
MPISASEARKTLFPLIERVNDDHVPVRISSKSGDAVLMSAADYDSWQETVYLLRSPANARRLMEAVARDKEGAASVAKSM
EELQDLAGDE

Download         Length: 273 bp

>AT139172 NZ_CP058546:c172978-172535 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9VSQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0M8UN66

References