Detailed information of TA system TA139164

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-DUF971
• Location: 2121636..2122213
• Replicon: chromosome
• Accession: NZ_CP043627
• Organism: Methylobacterium aquaticum strain BG2

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: F1D61_RS09440
• Protein ID: WP_203157618.1
• Coordinates: 2121636..2121929 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: F1D61_RS09445
• Protein ID: WP_203157619.1
• Coordinates: 2121932..2122213 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1D61_RS09430	2117524..2118894	+	1371	WP_203157617.1	N-acetylmuramoyl-L-alanine amidase	-
F1D61_RS09435	2119099..2121527	+	2429	Protein_1829	penicillin-binding protein 1A	-
F1D61_RS09440	2121636..2121929	+	294	WP_203157618.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F1D61_RS09445	2121932..2122213	+	282	WP_203157619.1	putative addiction module antidote protein	Antitoxin
F1D61_RS09450	2122343..2123471	+	1129	WP_203157620.1	peptide chain release factor 2	-
F1D61_RS09455	2123776..2126259	-	2484	WP_203157621.1	caspase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-91)

Antitoxin

• Uncharacterized protein HI1420 (5-82)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10835.51 Da
• Isoelectric Point: 10.7823

>T139164 WP_203157618.1 NZ_CP043627:2121636-2121929 [Methylobacterium aquaticum]
MIRIRQTKTYRRWEQQLKDPRARAAIAARLLRLANGLIGDAAPVGGGVSELRIHYGPGYRVYFQRRGDDIVILLCAGDKS
SQSRDIKKALQLAADEA

Nucleotide

• Length: 294 bp

>T139164 NZ_CP058544:2398398-2398730 [Klebsiella pneumoniae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 9803.03 Da
• Isoelectric Point: 3.9248

>AT139164 WP_203157619.1 NZ_CP043627:2121932-2122213 [Methylobacterium aquaticum]
MADEITDYDFAASLQTDEAIAVFLSDAFETGDANHIATALEIAVRAKGEARIASKEGMPEEGYDLDNPTLATLLAVMKAL
GVGFSPMPVRPAS

Nucleotide

• Length: 282 bp

>AT139164 NZ_CP058544:2398140-2398397 [Klebsiella pneumoniae]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA