Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 6333689..6334266 Replicon chromosome
Accession NZ_CP043626
Organism Pseudomonas denitrificans (nom. rej.) strain BG1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F1C79_RS29550 Protein ID WP_151189376.1
Coordinates 6334012..6334266 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F1C79_RS29545 Protein ID WP_081517291.1
Coordinates 6333689..6334015 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1C79_RS29525 6329700..6330881 + 1182 WP_151189374.1 two-component system response regulator -
F1C79_RS29530 6330954..6331850 + 897 WP_151189375.1 serine protein kinase RIO -
F1C79_RS29535 6331856..6332407 + 552 WP_151189786.1 nucleotidyltransferase family protein -
F1C79_RS29540 6332652..6333542 + 891 WP_081517290.1 EamA family transporter -
F1C79_RS29545 6333689..6334015 - 327 WP_081517291.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F1C79_RS29550 6334012..6334266 - 255 WP_151189376.1 type II toxin-antitoxin system HicA family toxin Toxin
F1C79_RS29555 6334358..6334759 - 402 WP_081517293.1 Cu(I)-responsive transcriptional regulator -
F1C79_RS29560 6334811..6337216 - 2406 WP_151189377.1 heavy metal translocating P-type ATPase -
F1C79_RS29565 6337320..6337802 - 483 WP_151189378.1 hypothetical protein -
F1C79_RS29570 6337956..6338153 + 198 WP_081517296.1 cation transporter -
F1C79_RS29575 6338190..6338822 - 633 WP_081517297.1 TetR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9460.97 Da        Isoelectric Point: 10.7951

>T139163 WP_151189376.1 NZ_CP043626:c6334266-6334012 [Pseudomonas denitrificans (nom. rej.)]
MNARHRRTLELIFSLPVPASLEWLRIESLLIALGAQVIEGNGSRVRFELNGIVATFHRPHPAKEAKPYQVRDARALLEQS
GIHP

Download         Length: 255 bp

>T139163 NZ_CP058544:1480994-1481404 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12061.60 Da        Isoelectric Point: 5.1406

>AT139163 WP_081517291.1 NZ_CP043626:c6334015-6333689 [Pseudomonas denitrificans (nom. rej.)]
MTPMKYQGYAARIEYSDDDRLFIGHIAGIRDVVGFHGESVNELRGAFEEAVDDYLATCAKLGREPQRPFSGKLSLRLDPQ
LHAQVAIKAELSNQSINQWVVDRLGEAV

Download         Length: 327 bp

>AT139163 NZ_CP058544:1480747-1481013 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References