Detailed information of TA system TA139160

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 5403619..5404124
• Replicon: chromosome
• Accession: NZ_CP043626
• Organism: Pseudomonas denitrificans (nom. rej.) strain BG1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: F1C79_RS24950
• Protein ID: WP_081518921.1
• Coordinates: 5403619..5403900 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0F0DQ93
• Locus tag: F1C79_RS24955
• Protein ID: WP_045213580.1
• Coordinates: 5403897..5404124 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1C79_RS24925	5400143..5400427	-	285	WP_151188881.1	hypothetical protein	-
F1C79_RS24930	5400609..5401559	+	951	WP_151188882.1	alpha/beta hydrolase	-
F1C79_RS24935	5401561..5402016	-	456	WP_151188883.1	GNAT family N-acetyltransferase	-
F1C79_RS24940	5402073..5402990	-	918	WP_151188884.1	LysR family transcriptional regulator	-
F1C79_RS24945	5403088..5403375	+	288	WP_081518922.1	DUF2218 domain-containing protein	-
F1C79_RS24950	5403619..5403900	-	282	WP_081518921.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F1C79_RS24955	5403897..5404124	-	228	WP_045213580.1	CopG family ribbon-helix-helix protein	Antitoxin
F1C79_RS24960	5404387..5405772	+	1386	WP_151188885.1	sodium:solute symporter	-
F1C79_RS24965	5405798..5406754	+	957	WP_151188886.1	agmatinase	-
F1C79_RS24970	5406830..5407753	+	924	WP_151188887.1	LysR family transcriptional regulator	-
F1C79_RS24975	5407750..5408469	+	720	WP_151188888.1	phytanoyl-CoA dioxygenase family protein	-
F1C79_RS24980	5408485..5408886	+	402	WP_151188889.1	GFA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10368.80 Da
• Isoelectric Point: 5.6642

>T139160 WP_081518921.1 NZ_CP043626:c5403900-5403619 [Pseudomonas denitrificans (nom. rej.)]
MSLQWTHKAAADLDAIYDHYVVLIGPEKALRAIQDIVEQVSPLANLEQSSSGVPSEVPGVRELLVERWPYQAAFRVKGRS
VQILRIDRVDNSG

Nucleotide

• Length: 282 bp

>T139160 NZ_CP043626:c5403900-5403619 [Pseudomonas denitrificans (nom. rej.)]
ATGAGCCTGCAGTGGACGCACAAGGCCGCCGCCGACCTGGATGCCATCTACGACCACTACGTCGTGCTGATCGGCCCGGA
GAAGGCGCTGCGGGCCATCCAGGACATCGTCGAGCAGGTCAGCCCGCTGGCGAACCTGGAACAAAGCAGCAGCGGCGTGC
CCAGCGAAGTGCCCGGCGTGCGCGAATTGCTGGTCGAGCGCTGGCCATACCAGGCCGCTTTCCGGGTAAAGGGGCGTTCT
GTGCAGATTTTGCGCATCGACCGTGTGGATAACTCGGGGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8243.21 Da
• Isoelectric Point: 5.9478

>AT139160 WP_045213580.1 NZ_CP043626:c5404124-5403897 [Pseudomonas denitrificans (nom. rej.)]
VTTVVSFRADDALVAALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGVADADAGHLLEHAAIEAKWGLA

Nucleotide

• Length: 228 bp

>AT139160 NZ_CP058544:975394-975615 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0F0DQ93