Detailed information of TA system TA139147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4813828..4815509
• Replicon: chromosome
• Accession: NZ_CP043597
• Organism: Klebsiella pneumoniae strain WCHKP085031

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: B7D33_RS23735
• Protein ID: WP_004146663.1
• Coordinates: 4813828..4814745 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A2L1C4M5
• Locus tag: B7D33_RS23740
• Protein ID: WP_004192584.1
• Coordinates: 4814751..4815509 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7D33_RS23715 (4809134)	4809134..4810654	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
B7D33_RS23720 (4810651)	4810651..4811649	+	999	WP_002885172.1	ribose ABC transporter permease	-
B7D33_RS23725 (4811680)	4811680..4812621	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
B7D33_RS23730 (4812696)	4812696..4813703	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
B7D33_RS23735 (4813828)	4813828..4814745	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
B7D33_RS23740 (4814751)	4814751..4815509	-	759	WP_004192584.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
B7D33_RS23745 (4815595)	4815595..4816323	-	729	WP_002885152.1	response regulator transcription factor	-
B7D33_RS23750 (4816596)	4816596..4818743	+	2148	WP_077598981.1	formate dehydrogenase subunit alpha	-
B7D33_RS23755 (4818973)	4818973..4819659	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T139147 WP_004146663.1 NZ_CP043597:c4814745-4813828 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T139147 NZ_CP058410:c165214-164963 [Trichlorobacter lovleyi]
ATGAATGCCCTGACCTATACCTATACGCGCCAGCATTTTGCAGAGGTCATGAAATCAGTAAATGAAGACCACGTTCCCGT
GGTGGTGACCAGCCAGCGCGGCAAACCGGTTGTCATCCTTTCCCTCGACGATTTCCACGCTTATGAAGAAACCGCCTATC
TGCTCCGTAATCCCCAAGGGGCCAAACGGTTGCTTGAATCTGTGGAGGAACTGCGTGCAGGCGGAGGGCAGACCAGAGAC
CTGACGGAATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28582.94 Da
• Isoelectric Point: 10.0870

>AT139147 WP_004192584.1 NZ_CP043597:c4815509-4814751 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT139147 NZ_CP058410:c164966-164712 [Trichlorobacter lovleyi]
ATGATGATAAAATTCTCAACCGCAGCATGGGAGGACTATCTCTACTGGCAGACTACCGACAAGGCGATGCTGAAACGGAT
CAATCAACTTATCCGGGATATCCAGCGAGAACCGTTTGCCGGTATCGGCAAGCCGGAACCGCTCAAACATCAATTGGCCG
GTTTCTGGTCACGCAGAATAGACAGCTGCCACCGCTTGGTCTATGCGGTTGAAGGTGATACGCTCCTGATTGCACAGTGT
AGAGATCATTATTGA

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A0A2L1C4M5