Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4382514..4383171 Replicon chromosome
Accession NZ_CP043597
Organism Klebsiella pneumoniae strain WCHKP085031

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag B7D33_RS21535 Protein ID WP_002916310.1
Coordinates 4382514..4382924 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag B7D33_RS21540 Protein ID WP_002916312.1
Coordinates 4382905..4383171 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D33_RS21515 (4378513) 4378513..4380246 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
B7D33_RS21520 (4380252) 4380252..4380966 - 715 Protein_4219 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B7D33_RS21525 (4380989) 4380989..4381885 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
B7D33_RS21530 (4381986) 4381986..4382507 + 522 WP_004144730.1 flavodoxin FldB -
B7D33_RS21535 (4382514) 4382514..4382924 - 411 WP_002916310.1 protein YgfX Toxin
B7D33_RS21540 (4382905) 4382905..4383171 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
B7D33_RS21545 (4383417) 4383417..4384400 + 984 WP_094645172.1 tRNA-modifying protein YgfZ -
B7D33_RS21550 (4384551) 4384551..4385210 - 660 WP_002916317.1 hemolysin III family protein -
B7D33_RS21555 (4385374) 4385374..4385685 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
B7D33_RS21560 (4385735) 4385735..4386463 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
B7D33_RS21565 (4386582) 4386582..4388015 + 1434 WP_004181234.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T139145 WP_002916310.1 NZ_CP043597:c4382924-4382514 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T139145 NZ_CP058410:122707-124017 [Trichlorobacter lovleyi]
TTGAGTACGGTTGCCGAAGTTAAGCTCTGGGGGAAGACCATCGGGGCGGTGGTTTTAGAAGACGGGAGAGATGTCGCTCT
GTTCGAGTACGATCCAGCTTTTGTTCGTAGCGGGATTGAGGTATCCCCTCTGGAGATGCCTCTGTCTGGTGGTGTGTACT
CGTTTCCGGCGTTGTCCCGTGATAGTTTTCACGGCCTCCCGGGCCTGCTCGCTGATTCACTCCCTGACAAGTATGGCAAT
GCGCTGATTGATGAATGGCTCGCTTTGCAGGGACGCTTGCCTGGTTCCATGAATGCGGTGGAGCGTTTGTGCTATACGGG
TAGCCGTGGCATGGGTGCTTTGGAGTATCTGCCGGCAACTGGTCCTAACCGATCAAAATCAGCAACACCAGTCGATATTG
ATCGCCTAGTCCAACTTGCCTCAGAAGTGCTTAACAGGCGAGGAGAATTGCAGGCATCATTTTGCAATGATGATCTAACA
GAATCGGCTTTGCTTGATATTTTGCGGGTCGGAACCTCAGCAGGGGGCGCTCGCGCGAAGGCGATTATTGCGTTTAACCC
AGAAACAAAAGAGGTCCGTTCTGGACAGGTTAAAGCACCGATTGGATTCGAATACTGGCTTATCAAGTTCGACGGGGTAT
CGGGCAACAAGGACAAGGAAAAGGTCAGCGACCCCCAAGGATTTGGCAAGATAGAGTATGCCTACTACCTGATGGCAAAA
GACTGCCATATTGATATGTCTGAGTGTGAGTTGCTGCACGAAAATGGCCGCAGCCACTTTATGACAAAACGCTTTGATCG
GTTGCCAAATGGAAGCAAGCTTCACATGCAGTCCCTGGCAGCCCTTGCCCATTATGATTTCAATGTGGCTGGAGTGAACA
GCTACGAGCAGGCGATGATGGTGTGCCGGCGAATCGGGGCGCCTGTCGGCTCGATCGAACAGATGTTCCGGCGGATGGCG
TTCAATATTGTGGCTCGCAACCAGGATGATCATGTCAAAAACATAGCCTTCCTTATGGACAAGAAGGGCAGCTGGGCGCT
GTCTCCTGCCTTCGATATGGCCTACAGCTATAATCCTACCGGCGATTGGACTGATAAGCACCAGATGTCAATGAACGGTA
AGCGCGATGGATTCGCACCTGACGATTTCAAGGAGTGCTCAAGGGTGGCAGGCCTCAAGCAAGGGCAGGGCTTGTCTATA
CTCCGGGAGGTCCAGTCTGTAGTTCTGAATTGGCCGGATTATGCTGGCAGAGCAGGTATTGACGAAAAGACTGCCGAGAG
TATCGCTGCTGCGCATCGCCTGAGCCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT139145 WP_002916312.1 NZ_CP043597:c4383171-4382905 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT139145 NZ_CP058410:122345-122710 [Trichlorobacter lovleyi]
TTGCGCTATAACAAAAATATGAAAATCACATCTAATCTAACTGACCAAACCGTCCTGCACGAACTGGGTGAACGACTAGC
CAGACGCAGAATAGAGCTCGCAAAAACCCAGATGCAGTTGGCTGAGGAGAGCGGGCTTGCCAGGCGCACAATTCAATATG
CTGAAGCTGGTAGATCTATCCAGAGCGAGAGTCTGGTGAGACTATTCCGTGCGCTGGGTTTGTTCGAAACGCTGGATGCC
TTGTTGCCTGAACAGCAGGTGAGTCCTATGGATTTGTTGAAGCTTAAGAAAAAAGCGCGGAAGCGGGTAAGGGCCGCGCA
GGTGGCCCAAGAAGCTGAAGATTGGCAGTGGGGGGATGAATCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References