Detailed information of TA system TA139136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2476752..2478340
• Replicon: chromosome
• Accession: NZ_CP043597
• Organism: Klebsiella pneumoniae strain WCHKP085031

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: B7D33_RS12005
• Protein ID: WP_049109073.1
• Coordinates: 2477018..2478340 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: B7D33_RS12000
• Protein ID: WP_002904790.1
• Coordinates: 2476752..2477018 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7D33_RS11975 (2471903)	2471903..2472826	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
B7D33_RS11980 (2472807)	2472807..2473961	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
B7D33_RS11985 (2474307)	2474307..2475686	+	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
B7D33_RS11990 (2475664)	2475664..2476164	+	501	WP_094645009.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
B7D33_RS11995 (2476161)	2476161..2476487	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
B7D33_RS12000 (2476752)	2476752..2477018	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
B7D33_RS12005 (2477018)	2477018..2478340	+	1323	WP_049109073.1	type II toxin-antitoxin system HipA family toxin	Toxin
B7D33_RS12010 (2478357)	2478357..2479649	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
B7D33_RS12015 (2479791)	2479791..2480795	-	1005	WP_016946380.1	fimbrial protein	-
B7D33_RS12020 (2480783)	2480783..2483284	-	2502	WP_094645008.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	iroE / mgtC	2441269..2688337	247068

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49115.40 Da
• Isoelectric Point: 7.5357

>T139136 WP_049109073.1 NZ_CP043597:2477018-2478340 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPAGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T139136 NZ_CP058363:2224-2499 [Klebsiella pneumoniae]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT139136 WP_002904790.1 NZ_CP043597:2476752-2477018 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT139136 NZ_CP058363:1940-2224 [Klebsiella pneumoniae]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTCATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8