Detailed information of TA system TA139132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 520469..520985
• Replicon: chromosome
• Accession: NZ_CP043597
• Organism: Klebsiella pneumoniae strain WCHKP085031

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B7D33_RS02570
• Protein ID: WP_094645165.1
• Coordinates: 520701..520985 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: B7D33_RS02565
• Protein ID: WP_002886901.1
• Coordinates: 520469..520711 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7D33_RS02550 (516497)	516497..517237	+	741	WP_002886899.1	KDGP aldolase family protein	-
B7D33_RS02555 (517304)	517304..518458	+	1155	WP_004178372.1	lactonase family protein	-
B7D33_RS02560 (518481)	518481..520391	+	1911	WP_009486549.1	PRD domain-containing protein	-
B7D33_RS02565 (520469)	520469..520711	+	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
B7D33_RS02570 (520701)	520701..520985	+	285	WP_094645165.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B7D33_RS02575 (520989)	520989..521453	-	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
B7D33_RS02580 (521782)	521782..523920	-	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
B7D33_RS02585 (524277)	524277..525020	-	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
B7D33_RS02590 (525023)	525023..525196	-	174	WP_032408826.1	hypothetical protein	-
B7D33_RS02595 (525326)	525326..525589	+	264	WP_014908078.1	PTS sugar transporter subunit IIB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11069.93 Da
• Isoelectric Point: 10.4962

>T139132 WP_094645165.1 NZ_CP043597:520701-520985 [Klebsiella pneumoniae]
MTYELEFDPRAWRGWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T139132 NZ_CP058361:c4792761-4792477 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT139132 WP_002886901.1 NZ_CP043597:520469-520711 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT139132 NZ_CP058361:c4792993-4792751 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0