Detailed information of TA system TA139127

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4757297..4757813
• Replicon: chromosome
• Accession: NZ_CP043590
• Organism: Klebsiella pneumoniae strain WCHKP040009

Toxin (Protein)

• Gene name: relE
• Uniprot ID: R4YAY3
• Locus tag: C6M58_RS23045
• Protein ID: WP_004178374.1
• Coordinates: 4757297..4757581 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A919M0P8
• Locus tag: C6M58_RS23050
• Protein ID: WP_032434351.1
• Coordinates: 4757571..4757813 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6M58_RS23020 (4752780)	4752780..4753043	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
C6M58_RS23025 (4753173)	4753173..4753346	+	174	WP_032414379.1	hypothetical protein	-
C6M58_RS23030 (4753349)	4753349..4754092	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
C6M58_RS23035 (4754449)	4754449..4756587	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
C6M58_RS23040 (4756829)	4756829..4757293	+	465	WP_004222151.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
C6M58_RS23045 (4757297)	4757297..4757581	-	285	WP_004178374.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C6M58_RS23050 (4757571)	4757571..4757813	-	243	WP_032434351.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C6M58_RS23055 (4757891)	4757891..4759801	-	1911	WP_004152270.1	PRD domain-containing protein	-
C6M58_RS23060 (4759824)	4759824..4760978	-	1155	WP_002886900.1	lactonase family protein	-
C6M58_RS23065 (4761044)	4761044..4761784	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11155.97 Da
• Isoelectric Point: 10.3787

>T139127 WP_004178374.1 NZ_CP043590:c4757581-4757297 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T139127 NZ_CP058361:1719469-1719801 [Klebsiella pneumoniae]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCCACCAGCGGCCATGAACAAAGCGGAAAACGTCCGGTACTCAT
CGTGTCGAAGGCATCATTTAACAAGCTGACCCAGCTACCCGTTATTGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAAAGGCAAGCGTCTGGAACGAATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9003.47 Da
• Isoelectric Point: 6.3340

>AT139127 WP_032434351.1 NZ_CP043590:c4757813-4757571 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Nucleotide

• Length: 243 bp

>AT139127 NZ_CP058361:1719211-1719468 [Klebsiella pneumoniae]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCCCCCGCCGTGCTGAAAACGCTGGGGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGGCTGCCTGGTTATTGAACCTCAAAAACGTCCTCACTATTCGC
TTGAAGAACTGCTGGCGCAGTGCGATCCGCACGCTGAAATAAGCGAAGGGGGGCGTGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTATAG

Structures

Toxin

• AlphaFold DB: A6THG1