Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4664569..4665272 Replicon chromosome
Accession NZ_CP043590
Organism Klebsiella pneumoniae strain WCHKP040009

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag C6M58_RS22655 Protein ID WP_071994632.1
Coordinates 4664569..4664910 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag C6M58_RS22660 Protein ID WP_032434296.1
Coordinates 4664931..4665272 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6M58_RS22645 (4660884) 4660884..4661753 + 870 WP_023317468.1 HNH endonuclease -
C6M58_RS22650 (4662344) 4662344..4664377 + 2034 WP_050598589.1 hypothetical protein -
C6M58_RS22655 (4664569) 4664569..4664910 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
C6M58_RS22660 (4664931) 4664931..4665272 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6M58_RS22665 (4665283) 4665283..4665825 - 543 WP_032434298.1 DNA repair protein RadC -
C6M58_RS22670 (4665838) 4665838..4666278 - 441 WP_032434300.1 antirestriction protein -
C6M58_RS22675 (4666309) 4666309..4667130 - 822 WP_032434301.1 DUF932 domain-containing protein -
C6M58_RS22680 (4667250) 4667250..4667723 - 474 WP_032434303.1 hypothetical protein -
C6M58_RS22685 (4667795) 4667795..4668247 - 453 WP_032410767.1 hypothetical protein -
C6M58_RS22690 (4668283) 4668283..4668999 - 717 WP_032434305.1 WYL domain-containing protein -
C6M58_RS22695 (4669243) 4669243..4670117 - 875 Protein_4452 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4652866..4698539 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T139126 WP_071994632.1 NZ_CP043590:c4664910-4664569 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

>T139126 NZ_CP043590:c4664910-4664569 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT139126 WP_032434296.1 NZ_CP043590:c4665272-4664931 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT139126 NZ_CP058361:782392-782658 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References