Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3992188..3992807 Replicon chromosome
Accession NZ_CP043590
Organism Klebsiella pneumoniae strain WCHKP040009

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag C6M58_RS19440 Protein ID WP_002892050.1
Coordinates 3992589..3992807 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag C6M58_RS19435 Protein ID WP_002892066.1
Coordinates 3992188..3992562 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6M58_RS19425 (3987340) 3987340..3988533 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C6M58_RS19430 (3988556) 3988556..3991702 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
C6M58_RS19435 (3992188) 3992188..3992562 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
C6M58_RS19440 (3992589) 3992589..3992807 + 219 WP_002892050.1 HHA domain-containing protein Toxin
C6M58_RS19445 (3992966) 3992966..3993532 + 567 WP_002892030.1 maltose O-acetyltransferase -
C6M58_RS19450 (3993504) 3993504..3993644 - 141 WP_004147370.1 hypothetical protein -
C6M58_RS19455 (3993665) 3993665..3994135 + 471 WP_002892026.1 YlaC family protein -
C6M58_RS19460 (3994110) 3994110..3995561 - 1452 WP_032435563.1 PLP-dependent aminotransferase family protein -
C6M58_RS19465 (3995662) 3995662..3996360 + 699 WP_032435564.1 GNAT family protein -
C6M58_RS19470 (3996357) 3996357..3996497 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
C6M58_RS19475 (3996497) 3996497..3996760 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T139124 WP_002892050.1 NZ_CP043590:3992589-3992807 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T139124 NZ_CP058360:2224-2499 [Klebsiella pneumoniae]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT139124 WP_002892066.1 NZ_CP043590:3992188-3992562 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT139124 NZ_CP058360:1940-2224 [Klebsiella pneumoniae]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTCATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References