Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 813876..814533 Replicon chromosome
Accession NZ_CP043588
Organism Klebsiella pneumoniae subsp. pneumoniae strain WCHKP015096

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CLR01_RS04070 Protein ID WP_002916310.1
Coordinates 814123..814533 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CLR01_RS04065 Protein ID WP_002916312.1
Coordinates 813876..814142 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLR01_RS04040 (809032) 809032..810465 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
CLR01_RS04045 (810584) 810584..811312 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CLR01_RS04050 (811362) 811362..811673 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
CLR01_RS04055 (811837) 811837..812496 + 660 WP_002916317.1 hemolysin III family protein -
CLR01_RS04060 (812647) 812647..813630 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
CLR01_RS04065 (813876) 813876..814142 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CLR01_RS04070 (814123) 814123..814533 + 411 WP_002916310.1 protein YgfX Toxin
CLR01_RS04075 (814540) 814540..815061 - 522 WP_004144730.1 flavodoxin FldB -
CLR01_RS04080 (815162) 815162..816058 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CLR01_RS04085 (816081) 816081..816794 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CLR01_RS04090 (816800) 816800..818533 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T139095 WP_002916310.1 NZ_CP043588:814123-814533 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T139095 NZ_CP058355:667741-668055 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT139095 WP_002916312.1 NZ_CP043588:813876-814142 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT139095 NZ_CP043588:813876-814142 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References