Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | kacAT/DUF1778(antitoxin) |
| Location | 30457..31261 | Replicon | plasmid p1_020151 |
| Accession | NZ_CP043587 | ||
| Organism | Klebsiella pneumoniae subsp. ozaenae strain SCKP020151 | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | - |
| Locus tag | CLQ49_RS26030 | Protein ID | WP_072198182.1 |
| Coordinates | 30457..30984 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | KacA | Uniprot ID | - |
| Locus tag | CLQ49_RS26035 | Protein ID | WP_048264996.1 |
| Coordinates | 30992..31261 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CLQ49_RS26005 (CLQ49_26165) | 26097..27278 | + | 1182 | WP_023345579.1 | MFS transporter | - |
| CLQ49_RS26010 (CLQ49_26170) | 27397..28005 | - | 609 | WP_023345578.1 | short chain dehydrogenase | - |
| CLQ49_RS26015 (CLQ49_26175) | 28103..29005 | + | 903 | WP_048265000.1 | LysR family transcriptional regulator | - |
| CLQ49_RS26025 (CLQ49_26185) | 30065..30373 | - | 309 | WP_048264999.1 | hypothetical protein | - |
| CLQ49_RS26030 (CLQ49_26190) | 30457..30984 | - | 528 | WP_072198182.1 | GNAT family N-acetyltransferase | Toxin |
| CLQ49_RS26035 (CLQ49_26195) | 30992..31261 | - | 270 | WP_048264996.1 | DUF1778 domain-containing protein | Antitoxin |
| CLQ49_RS26040 (CLQ49_26200) | 31894..34257 | - | 2364 | WP_048264995.1 | hypothetical protein | - |
| CLQ49_RS26045 (CLQ49_26205) | 34272..35018 | - | 747 | WP_048264994.1 | ABC transporter permease | - |
| CLQ49_RS26050 (CLQ49_26210) | 35015..36007 | - | 993 | WP_048264993.1 | ABC transporter substrate-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | iroN / ybtS / ybtX / ybtQ / ybtP / ybtA / irp2 / irp1 / ybtU / ybtT / ybtE / fyuA | 1..163125 | 163125 | |
| - | flank | IS/Tn | - | - | 29317..29820 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 20078.04 Da Isoelectric Point: 5.7389
>T139093 WP_072198182.1 NZ_CP043587:c30984-30457 [Klebsiella pneumoniae subsp. ozaenae]
VMQELAIEMINDEFDYDIGEFDCGEETLNTFLKDHLKRQHDGQILKGYVLVTKEQKPKLLGYYTLSGSCFERKMLPSKTQ
QRKIPYQNAPSITLGRLAIDKSIQGQGWGELLVTHAMNVVWDASKAVGIYGLFVEALNDKAKRFYTRLDFIQLVGENSNL
LFYPTKSIEKIFTEE
VMQELAIEMINDEFDYDIGEFDCGEETLNTFLKDHLKRQHDGQILKGYVLVTKEQKPKLLGYYTLSGSCFERKMLPSKTQ
QRKIPYQNAPSITLGRLAIDKSIQGQGWGELLVTHAMNVVWDASKAVGIYGLFVEALNDKAKRFYTRLDFIQLVGENSNL
LFYPTKSIEKIFTEE
Download Length: 528 bp
>T139093 NZ_CP058355:210211-210318 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10148.65 Da Isoelectric Point: 10.1733
>AT139093 WP_048264996.1 NZ_CP043587:c31261-30992 [Klebsiella pneumoniae subsp. ozaenae]
MSALRKQRIDLRLTDDDKSLIEEAAAMSNQTITQFVVASASERAAEVIEQHRRMVLNEESWNLVMDAIANPAAPNERLKR
AAKRLQKMR
MSALRKQRIDLRLTDDDKSLIEEAAAMSNQTITQFVVASASERAAEVIEQHRRMVLNEESWNLVMDAIANPAAPNERLKR
AAKRLQKMR
Download Length: 270 bp
>AT139093 NZ_CP058355:c210163-210097 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|