Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4724971..4725487 Replicon chromosome
Accession NZ_CP043585
Organism Klebsiella pneumoniae subsp. ozaenae strain SCKP020151

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag CLQ49_RS22795 Protein ID WP_004894697.1
Coordinates 4724971..4725255 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CLQ49_RS22800 Protein ID WP_002886901.1
Coordinates 4725245..4725487 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ49_RS22770 (CLQ49_22900) 4720366..4720629 - 264 WP_031280360.1 PTS sugar transporter subunit IIB -
CLQ49_RS22775 4720759..4720932 + 174 WP_002886906.1 hypothetical protein -
CLQ49_RS22780 (CLQ49_22905) 4720935..4721678 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
CLQ49_RS22785 (CLQ49_22910) 4722036..4724174 + 2139 WP_102040367.1 anaerobic ribonucleoside-triphosphate reductase -
CLQ49_RS22790 (CLQ49_22915) 4724503..4724967 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CLQ49_RS22795 (CLQ49_22920) 4724971..4725255 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLQ49_RS22800 (CLQ49_22925) 4725245..4725487 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CLQ49_RS22805 (CLQ49_22930) 4725565..4727475 - 1911 WP_023325426.1 PRD domain-containing protein -
CLQ49_RS22810 (CLQ49_22935) 4727498..4728652 - 1155 WP_004178372.1 lactonase family protein -
CLQ49_RS22815 (CLQ49_22940) 4728719..4729459 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T139090 WP_004894697.1 NZ_CP043585:c4725255-4724971 [Klebsiella pneumoniae subsp. ozaenae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T139090 NZ_CP058354:c2427900-2427547 [Bradyrhizobium japonicum]
ATGAAGCGAGGTGAGATCTGGACGGTGGCAGGCGGCAAGGACTATGCGGGCAAGCCGCGCCCCGTCGTCATCGTGCAGGA
CGACAGCTTCGACGCCACGAACTCGATCACTGTCTGCGCTTTCACAACCGACGAAACCGAGGCGCCGCTTTTCCGGCTCA
AGGTCGAGCCAAACGACAACAACGGCCTTCGAGTGCCGTCCCGGCTGATGGTCGATAAGATTACCACGGTGCCGAAAGCC
AAGGTGGGAACGCTAGTCGGTCGCCTAGACGATGACGACCTCTTGCGTCTCAACCGCGCTGTGCTGGTGTTCCTTGGACT
GGCTGGTTCGCAGAGAAGCGCCAGCGCAGATTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT139090 WP_002886901.1 NZ_CP043585:c4725487-4725245 [Klebsiella pneumoniae subsp. ozaenae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT139090 NZ_CP058354:c2428118-2427897 [Bradyrhizobium japonicum]
ATGAGCCCTTCAAAGCCCAAGCCGTCTCGTCTGAAGGTGCAGGCCCACCGTGATCGATTGCGCGCACAAGGCCTGCGGCC
GATTCAGATTTGGGTGCCGGATATTCGCTCTCCGTCCTTTCGATCGGAAGCCCATCGCCAATCGCTTGCGGTCGCGACCA
GTGTACATGCATCCGAAGACCAGGGCTTCATCGACGCCGTATCCGATTGGACGGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References