Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2613106..2614694 | Replicon | chromosome |
| Accession | NZ_CP043585 | ||
| Organism | Klebsiella pneumoniae subsp. ozaenae strain SCKP020151 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A9J6RYF8 |
| Locus tag | CLQ49_RS12755 | Protein ID | WP_004892016.1 |
| Coordinates | 2613106..2614428 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | CLQ49_RS12760 | Protein ID | WP_004176198.1 |
| Coordinates | 2614428..2614694 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CLQ49_RS12740 (CLQ49_12835) | 2608163..2610663 | + | 2501 | Protein_2494 | fimbrial biogenesis outer membrane usher protein | - |
| CLQ49_RS12745 (CLQ49_12840) | 2610651..2611655 | + | 1005 | WP_004892012.1 | fimbrial protein | - |
| CLQ49_RS12750 (CLQ49_12850) | 2611797..2613089 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| CLQ49_RS12755 (CLQ49_12855) | 2613106..2614428 | - | 1323 | WP_004892016.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| CLQ49_RS12760 (CLQ49_12860) | 2614428..2614694 | - | 267 | WP_004176198.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| CLQ49_RS12765 (CLQ49_12865) | 2614959..2615285 | - | 327 | WP_004892019.1 | hydroxyisourate hydrolase | - |
| CLQ49_RS12770 (CLQ49_12870) | 2615282..2615782 | - | 501 | WP_004892023.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| CLQ49_RS12775 (CLQ49_12875) | 2615760..2617139 | - | 1380 | WP_004176204.1 | nucleobase:cation symporter-2 family protein | - |
| CLQ49_RS12780 (CLQ49_12880) | 2617485..2618639 | + | 1155 | WP_004892025.1 | FAD-dependent urate hydroxylase HpxO | - |
| CLQ49_RS12785 (CLQ49_12885) | 2618620..2619543 | - | 924 | WP_004892028.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | mgtC / iroE | 2409638..2650177 | 240539 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49141.44 Da Isoelectric Point: 7.5357
>T139086 WP_004892016.1 NZ_CP043585:c2614428-2613106 [Klebsiella pneumoniae subsp. ozaenae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T139086 NZ_CP058353:c3334589-3334236 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGACCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATGGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGACCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATGGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9936.36 Da Isoelectric Point: 8.5912
>AT139086 WP_004176198.1 NZ_CP043585:c2614694-2614428 [Klebsiella pneumoniae subsp. ozaenae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT139086 NZ_CP058353:c3334231-3333929 [Serratia marcescens]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGTCCGAGGTCGTAGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATTA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATCGAACTGCCGGACGGCTCTCACTACGAGTTAGTGCTGTAA
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGTCCGAGGTCGTAGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATTA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATCGAACTGCCGGACGGCTCTCACTACGAGTTAGTGCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|