Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 5872..6397 Replicon plasmid pCTX15_020018
Accession NZ_CP043583
Organism Klebsiella pneumoniae strain SCKP020018

Toxin (Protein)


Gene name ccdB Uniprot ID D4HQE7
Locus tag C6M74_RS27890 Protein ID WP_013023785.1
Coordinates 5872..6177 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag C6M74_RS27895 Protein ID WP_001568025.1
Coordinates 6179..6397 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6M74_RS27860 (C6M74_28220) 1567..2193 + 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -
C6M74_RS27865 2190..2492 + 303 WP_004197636.1 hypothetical protein -
C6M74_RS27870 (C6M74_28230) 2948..3742 - 795 WP_004197635.1 site-specific integrase -
C6M74_RS27875 (C6M74_28235) 3940..4956 - 1017 WP_017899884.1 hypothetical protein -
C6M74_RS27880 (C6M74_28240) 4967..5281 - 315 WP_053389906.1 hypothetical protein -
C6M74_RS27885 (C6M74_28245) 5308..5703 - 396 WP_017899885.1 hypothetical protein -
C6M74_RS27890 (C6M74_28250) 5872..6177 - 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB Toxin
C6M74_RS27895 (C6M74_28255) 6179..6397 - 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
C6M74_RS27900 (C6M74_28275) 7215..7505 - 291 WP_013023783.1 hypothetical protein -
C6M74_RS27905 (C6M74_28280) 7502..8629 - 1128 WP_013023782.1 DUF4238 domain-containing protein -
C6M74_RS27910 (C6M74_28285) 8663..10255 - 1593 WP_015344964.1 hypothetical protein -
C6M74_RS27915 (C6M74_28290) 10462..11241 - 780 WP_013023780.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / qnrS1 - 1..103693 103693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11615.30 Da        Isoelectric Point: 6.4672

>T139072 WP_013023785.1 NZ_CP043583:c6177-5872 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T139072 NZ_CP043583:c6177-5872 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT139072 WP_001568025.1 NZ_CP043583:c6397-6179 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT139072 NZ_CP058350:1498613-1499059 [Rhizobium sp. ADMK78]
ATGTCGCAATTGCTAGAACGCCCAATATTGCCAACGGCGGACGATACCGAATTGGCCGCTCAGGCTAGTCGCTACATATC
GCGCGCAAAACACGAGGGTGCGGAACTCCGCGTCCAAGTGGACGGCGGCGAGCCGCTGAAGCTCCCGAGAGCCGTGAGCG
AATTGCTCTACCACCTGTTGACGGAGATGGCCCAAGGTAATGCCGTAACGGTGATCCCTGTGCATGCCGAGCTCACAACT
CAAGAGGCAGCAGATCAGCTCAATGTGTCGCGGCCCTACCTGATAAAGCTGCTGGAAGAAGGAAAAATCCCGTTTCACAT
GGTCGGCAGCCATCGCCGCATAAAATTCAGCGACCTCGATAACTTTCGCCGAAAGGCGGAGGATGAAAGGAAGCGGCTCA
TGGACGAGCTTGCCGAGCAAGCGCAGAAACTGGGGATGGGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZZW6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References