Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 102318..103228 | Replicon | plasmid pVir_020018 |
| Accession | NZ_CP043581 | ||
| Organism | Klebsiella pneumoniae strain SCKP020018 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | C6M74_RS26810 | Protein ID | WP_004026354.1 |
| Coordinates | 102318..102788 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | C6M74_RS26815 | Protein ID | WP_004026357.1 |
| Coordinates | 102785..103228 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C6M74_RS26770 (C6M74_27060) | 97402..98004 | - | 603 | WP_011251277.1 | HAD domain-containing protein | - |
| C6M74_RS26775 (C6M74_27065) | 98007..98522 | - | 516 | WP_041937820.1 | hypothetical protein | - |
| C6M74_RS26780 (C6M74_27070) | 98630..99205 | - | 576 | WP_074424927.1 | hypothetical protein | - |
| C6M74_RS26785 (C6M74_27075) | 99322..100278 | - | 957 | WP_011251280.1 | DsbA family protein | - |
| C6M74_RS26790 (C6M74_27080) | 100338..100679 | - | 342 | WP_011251281.1 | hypothetical protein | - |
| C6M74_RS26795 (C6M74_27085) | 100693..101004 | - | 312 | WP_011251282.1 | hypothetical protein | - |
| C6M74_RS26800 (C6M74_27090) | 101021..101470 | - | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| C6M74_RS26810 (C6M74_27100) | 102318..102788 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| C6M74_RS26815 (C6M74_27105) | 102785..103228 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| C6M74_RS26820 (C6M74_27110) | 103329..103832 | - | 504 | Protein_112 | DUF4113 domain-containing protein | - |
| C6M74_RS26825 (C6M74_27115) | 103930..104151 | - | 222 | WP_004213643.1 | DUF2188 domain-containing protein | - |
| C6M74_RS26830 (C6M74_27120) | 104326..104451 | - | 126 | Protein_114 | Fe3+-citrate ABC transporter substrate-binding protein | - |
| C6M74_RS26835 (C6M74_27125) | 104526..106652 | - | 2127 | WP_004213640.1 | TonB-dependent Fe(3+) dicitrate receptor FecA | - |
| C6M74_RS26840 (C6M74_27130) | 106739..107692 | - | 954 | Protein_116 | fec operon regulator FecR | - |
| C6M74_RS26845 (C6M74_27135) | 107689..108210 | - | 522 | WP_004213635.1 | ferric citrate uptake sigma factor FecI | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA | 1..229186 | 229186 | |
| - | flank | IS/Tn | - | - | 101472..101975 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T139070 WP_004026354.1 NZ_CP043581:c102788-102318 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T139070 NZ_CP058350:c377193-376822 [Rhizobium sp. ADMK78]
ATGGTCCGCAGCGGTGTTCCTCGCCGGGGCGATGTCTACTGGATCGATCCCAATCCGGTCGCCGGGCGCGAAATGAAAAA
CCGGCATAGGTTCGTTGTCATTACGCCGCATGAAATCAATGTATTCGGTGTGTGCATGACCGTTCCGGTGACTACTGGCG
GTGCCTTCACACGTGACATCGGACTTGCCGTGCCAATCCACGGACACGATACGACGGGTATCGCGGTCTGCAATCAAGTG
CGCAGTTTCGATATCGCGGCCCGAGTTCAGCAACGTTCGGCGAGTTTCATCGAGACGTTGGACAAGGCGACGGTCGACGA
GATTGTTGCCCGCGTCGTCAGCGCCATCGATCCGTTGCCAGGCTCGGTTTGA
ATGGTCCGCAGCGGTGTTCCTCGCCGGGGCGATGTCTACTGGATCGATCCCAATCCGGTCGCCGGGCGCGAAATGAAAAA
CCGGCATAGGTTCGTTGTCATTACGCCGCATGAAATCAATGTATTCGGTGTGTGCATGACCGTTCCGGTGACTACTGGCG
GTGCCTTCACACGTGACATCGGACTTGCCGTGCCAATCCACGGACACGATACGACGGGTATCGCGGTCTGCAATCAAGTG
CGCAGTTTCGATATCGCGGCCCGAGTTCAGCAACGTTCGGCGAGTTTCATCGAGACGTTGGACAAGGCGACGGTCGACGA
GATTGTTGCCCGCGTCGTCAGCGCCATCGATCCGTTGCCAGGCTCGGTTTGA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT139070 WP_004026357.1 NZ_CP043581:c103228-102785 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT139070 NZ_CP058350:c377459-377193 [Rhizobium sp. ADMK78]
ATGACGGTAACGACGAAGGTACGAAAGCAGGGTGGAGCTGCGGTGGTCACCATTCCGCCAGCGCTGCTCAAGCTCATGGC
CGTCGAGGTTGGTGATCAGCTGTCTCTCGATGTCCAGAACGGCGAGTTGGTGGCAAAGCCACTGCGGGCCGGTGTCAAGC
GCTATACTCTGGCGGAATTGCTGGTCGGTGCCGAAGAACTGGCTCAACTCAATGCTTCTTTGGCTGAGACCATGGACGGC
GATGCCATTGGTCGCGAGATCGGCTGA
ATGACGGTAACGACGAAGGTACGAAAGCAGGGTGGAGCTGCGGTGGTCACCATTCCGCCAGCGCTGCTCAAGCTCATGGC
CGTCGAGGTTGGTGATCAGCTGTCTCTCGATGTCCAGAACGGCGAGTTGGTGGCAAAGCCACTGCGGGCCGGTGTCAAGC
GCTATACTCTGGCGGAATTGCTGGTCGGTGCCGAAGAACTGGCTCAACTCAATGCTTCTTTGGCTGAGACCATGGACGGC
GATGCCATTGGTCGCGAGATCGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |