Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4914710..4915226 Replicon chromosome
Accession NZ_CP043580
Organism Klebsiella pneumoniae strain SCKP020018

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag C6M74_RS23655 Protein ID WP_004178374.1
Coordinates 4914710..4914994 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C6M74_RS23660 Protein ID WP_002886901.1
Coordinates 4914984..4915226 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6M74_RS23630 (4910106) 4910106..4910369 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
C6M74_RS23635 (4910499) 4910499..4910672 + 174 WP_041169004.1 hypothetical protein -
C6M74_RS23640 (4910675) 4910675..4911418 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
C6M74_RS23645 (4911775) 4911775..4913913 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
C6M74_RS23650 (4914242) 4914242..4914706 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C6M74_RS23655 (4914710) 4914710..4914994 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6M74_RS23660 (4914984) 4914984..4915226 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C6M74_RS23665 (4915304) 4915304..4917214 - 1911 WP_012737231.1 PRD domain-containing protein -
C6M74_RS23670 (4917237) 4917237..4918391 - 1155 WP_012737230.1 lactonase family protein -
C6M74_RS23675 (4918458) 4918458..4919198 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T139067 WP_004178374.1 NZ_CP043580:c4914994-4914710 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T139067 NZ_CP058349:3975157-3975561 [Pseudomonas sp. ABC1]
ATGCTGAAGTTCATGCTCGATACCAACATTTGCATCTTCACCATCAAGAATCGGCCGGAGCAGGTACGTGAGACCTTCAA
GCGCCACTCAGGGCAGTTGAGCATCAGCACGATCACATTGATGGAACTGATCTATGGTGCGGAGAAGTCCTCCAACCCCG
AGCGTAACCTGGCTGACGTTGAAGGCTTTGCAGCACGACTGGACGTCCTGCCCTATGACAGCCAGGCGGCGACTCACTCG
GGTCAACTGCGTTCCGAACTGGCCCGTGTTGGCAAACCGATAGGCCCGTACGACCAGATGATTGCAGGGCACGCTCGCTC
CCAAGGACTGATTCTGGTGACGAATAATCTTCGAGAGTTCGAGCGCGTCCCAGGTTTGCGAGTAGAGGACTGGGTGAATC
CCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT139067 WP_002886901.1 NZ_CP043580:c4915226-4914984 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT139067 NZ_CP058349:3974927-3975157 [Pseudomonas sp. ABC1]
ATGGAACAAGGTGCTGTTTTCCAGAGCAACCGCAGCCAGGCGGTGCGATTACCCAAGGCAGTAGCACTGCCTGAGGATGT
AAAGCGGGTCGATGTCGTGGTGGTGGGGCGTACCCGGATCATTACCCCGGCAGGCGAGGCGTGGGATAGCTGGTTCGATG
GCGAGGGTGTGACCGCCGACTACATGGCCGATCGTGAACAGCCAGCAGACCAGGAGCGGGATGCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References