Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797246..797903 Replicon chromosome
Accession NZ_CP043580
Organism Klebsiella pneumoniae strain SCKP020018

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag C6M74_RS03960 Protein ID WP_002916310.1
Coordinates 797493..797903 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag C6M74_RS03955 Protein ID WP_002916312.1
Coordinates 797246..797512 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6M74_RS03930 (792448) 792448..793881 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
C6M74_RS03935 (794000) 794000..794728 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
C6M74_RS03940 (794778) 794778..795095 + 318 WP_077274463.1 N(4)-acetylcytidine aminohydrolase -
C6M74_RS03945 (795259) 795259..795918 + 660 WP_002916317.1 hemolysin III family protein -
C6M74_RS03950 (796017) 796017..797000 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
C6M74_RS03955 (797246) 797246..797512 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
C6M74_RS03960 (797493) 797493..797903 + 411 WP_002916310.1 protein YgfX Toxin
C6M74_RS03965 (797910) 797910..798431 - 522 WP_002916308.1 flavodoxin FldB -
C6M74_RS03970 (798532) 798532..799428 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
C6M74_RS03975 (799451) 799451..800164 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C6M74_RS03980 (800170) 800170..801903 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T139055 WP_002916310.1 NZ_CP043580:797493-797903 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T139055 NZ_CP058344:c20609-20451 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT139055 WP_002916312.1 NZ_CP043580:797246-797512 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT139055 NZ_CP058344:c20877-20653 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References