Detailed information of TA system TA139052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2567231..2568795
• Replicon: chromosome
• Accession: NZ_CP043579
• Organism: Aeromonas media strain R1-26

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2S4TP05
• Locus tag: F0Q17_RS11860
• Protein ID: WP_005329232.1
• Coordinates: 2567485..2568795 (+)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: F0Q17_RS11855
• Protein ID: WP_005329233.1
• Coordinates: 2567231..2567485 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0Q17_RS11830	2562806..2563312	-	507	WP_182310005.1	hypothetical protein	-
F0Q17_RS11835	2563716..2564168	-	453	WP_021140686.1	DUF2384 domain-containing protein	-
F0Q17_RS11840	2564348..2565730	+	1383	WP_197060245.1	Fic family protein	-
F0Q17_RS11845	2565809..2566060	+	252	WP_010674977.1	plasmid stabilization protein	-
F0Q17_RS11850	2566481..2566729	-	249	WP_010674978.1	hypothetical protein	-
F0Q17_RS11855	2567231..2567485	+	255	WP_005329233.1	helix-turn-helix domain-containing protein	Antitoxin
F0Q17_RS11860	2567485..2568795	+	1311	WP_005329232.1	type II toxin-antitoxin system HipA family toxin	Toxin
F0Q17_RS11870	2569909..2572083	+	2175	WP_182310006.1	catalase/peroxidase HPI	-
F0Q17_RS11885	2572852..2573229	-	378	WP_182310007.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49096.31 Da
• Isoelectric Point: 7.1717

>T139052 WP_005329232.1 NZ_CP043579:2567485-2568795 [Aeromonas media]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQIMTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSKAQRLKR

Nucleotide

• Length: 1311 bp

>T139052 NZ_CP058343:c66661-66455 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCTTTGCTGAGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGAG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9271.66 Da
• Isoelectric Point: 9.1571

>AT139052 WP_005329233.1 NZ_CP043579:2567231-2567485 [Aeromonas media]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Nucleotide

• Length: 255 bp

>AT139052 NZ_CP058343:66648-66709 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A2S4TP05