Detailed information of TA system TA139049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 135766..137349
• Replicon: chromosome
• Accession: NZ_CP043578
• Organism: Stenotrophomonas maltophilia strain T50-20

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: F0Q13_RS00600
• Protein ID: WP_182267006.1
• Coordinates: 135766..137088 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: M5CTC8
• Locus tag: F0Q13_RS00605
• Protein ID: WP_004134030.1
• Coordinates: 137092..137349 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0Q13_RS00585	131162..132796	-	1635	WP_180844550.1	TldD/PmbA family protein	-
F0Q13_RS00590	132827..134458	-	1632	WP_182267004.1	TldD/PmbA family protein	-
F0Q13_RS00595	135151..135765	+	615	WP_182267005.1	DUF938 domain-containing protein	-
F0Q13_RS00600	135766..137088	-	1323	WP_182267006.1	type II toxin-antitoxin system HipA family toxin	Toxin
F0Q13_RS00605	137092..137349	-	258	WP_004134030.1	helix-turn-helix transcriptional regulator	Antitoxin
F0Q13_RS00610	137507..141193	-	3687	WP_182267007.1	indolepyruvate ferredoxin oxidoreductase family protein	-
F0Q13_RS00615	141362..141997	+	636	WP_182267008.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 48780.54 Da
• Isoelectric Point: 6.8740

>T139049 WP_182267006.1 NZ_CP043578:c137088-135766 [Stenotrophomonas maltophilia]
MGTLRVWMNGVEVALWNDVRSGSSRLSYVDSWISSAQSRPLSLSLPLLPEGESHRGDVVNNYFDNLLPDNAVIRNRIRDR
FSTRSSDTFDLLEAIGRDCVGAVQLLPLSHTPGDIQQITCEALDESGVAAILRQVTAGNLPGAPTSDDAFRISIAGAQEK
TGLLLHAGQWCIPTGSTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMQLLSAFGIPVANTQMGRFKDERALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVTIMDLLRQSEHFEDRATFFKTQILFWMLAATDGHAKNFSVYLE
AGGRFRLTPVYDVLSVHPILGRGPNQLDPRNAQLAMSVQGKNRHRKLHLVRRRHWNETARACGVADGAEPWIEALIAAVE
PAIEQVTRQLPGDFPVNVSEPIFNGLRAAAARLSSMSPDA

Nucleotide

• Length: 1323 bp

>T139049 NZ_CP058342:c4089018-4088731 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9550.01 Da
• Isoelectric Point: 12.0740

>AT139049 WP_004134030.1 NZ_CP043578:c137349-137092 [Stenotrophomonas maltophilia]
MDRPLHTVRTPQQLAPLMRAFRRQAGLSQAQLAAQLGISRQAVGALERDPASASFERLMRVWAVLGLEVRLQQRSPPETT
STLEW

Nucleotide

• Length: 258 bp

>AT139049 NZ_CP058342:c4088744-4088442 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: M5CTC8