Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 566307..566809 Replicon chromosome
Accession NZ_CP043575
Organism Comamonas koreensis strain T50-37

Toxin (Protein)


Gene name yoeB Uniprot ID Q5XQD8
Locus tag F0Q04_RS02645 Protein ID WP_032492620.1
Coordinates 566307..566561 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V0BEH6
Locus tag F0Q04_RS02650 Protein ID WP_032492621.1
Coordinates 566558..566809 (-) Length 84 a.a.

Genomic Context

F0Q04_RS02605F0Q04_RS02610F0Q04_RS02615F0Q04_RS02620F0Q04_RS02625F0Q04_RS02630F0Q04_RS02640F0Q04_RS02655F0Q04_RS02660F0Q04_RS02665F0Q04_RS02670F0Q04_RS02675F0Q04_RS02635F0Q04_RS02645F0Q04_RS02650
Location: 561318..561653 (336 bp)
Type: Others
Protein ID: WP_182344325.1
Location: 561680..562642 (963 bp)
Type: Others
Protein ID: WP_182344327.1
Location: 562663..562959 (297 bp)
Type: Others
Protein ID: WP_182283343.1
Location: 563032..563313 (282 bp)
Type: Others
Protein ID: WP_182283342.1
Location: 563335..563508 (174 bp)
Type: Others
Protein ID: WP_182283341.1
Location: 563965..564669 (705 bp)
Type: Others
Protein ID: WP_001067855.1
Location: 565680..566234 (555 bp)
Type: Others
Protein ID: WP_003159191.1
Location: 566983..567537 (555 bp)
Type: Others
Protein ID: WP_014454105.1
Location: 567642..568894 (1253 bp)
Type: Others
Protein ID: Protein_519
Location: 568992..569819 (828 bp)
Type: Others
Protein ID: WP_014386432.1
Location: 569867..570340 (474 bp)
Type: Others
Protein ID: WP_071846295.1
Location: 570532..570879 (348 bp)
Type: Others
Protein ID: WP_000679427.1
Location: 564722..565519 (798 bp)
Type: Others
Protein ID: Protein_514
Location: 566307..566561 (255 bp)
Type: Toxin
Protein ID: WP_032492620.1
Location: 566558..566809 (252 bp)
Type: Antitoxin
Protein ID: WP_032492621.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
F0Q04_RS02605561318..561653+336WP_182344325.1hypothetical protein-
F0Q04_RS02610561680..562642+963WP_182344327.1hypothetical protein-
F0Q04_RS02615562663..562959+297WP_182283343.1H-NS histone family protein-
F0Q04_RS02620563032..563313+282WP_182283342.1hypothetical protein-
F0Q04_RS02625563335..563508+174WP_182283341.1hypothetical protein-
F0Q04_RS02630563965..564669+705WP_001067855.1IS6-like element IS26 family transposase-
F0Q04_RS02635564722..565519-798Protein_514class 1 integron integrase IntI1-
F0Q04_RS02640565680..566234+555WP_003159191.1aminoglycoside N-acetyltransferase AAC(6')-Ib4-
F0Q04_RS02645566307..566561-255WP_032492620.1Txe/YoeB family addiction module toxinToxin
F0Q04_RS02650566558..566809-252WP_032492621.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
F0Q04_RS02655566983..567537+555WP_014454105.1aminoglycoside N-acetyltransferase AAC(6')-Ib'-
F0Q04_RS02660567642..568894+1253Protein_519EreA family erythromycin esterase-
F0Q04_RS02665568992..569819+828WP_014386432.1OXA-2 family oxacillin-hydrolyzing class D beta-lactamase OXA-21-
F0Q04_RS02670569867..570340+474WP_071846295.1trimethoprim-resistant dihydrofolate reductase DfrA1-
F0Q04_RS02675570532..570879+348WP_000679427.1quaternary ammonium compound efflux SMR transporter QacE delta 1-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandaac(6')-Ib / ere(A) / blaOXA-21 / floR / aph(3'')-Ib / aph(6)-Id / tet(G) / sul1 / aph(3')-Ib / ant(3'')-Ia-561006..60410143095
-insideIScluster/Tnaac(6')-Ib / ere(A) / blaOXA-21 / floR / aph(3'')-Ib / aph(6)-Id / tet(G) / sul1 / aph(3')-Ib / ant(3'')-Ia-559420..60173442314
-insideIntegron--564560..5688944334


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10272.81 Da        Isoelectric Point: 9.3585

>T139044 WP_032492620.1 NZ_CP043575:c566561-566307 [Comamonas koreensis]
MRLIFSDDAWEDYLFWQKQDRRMVDRINKLIKETTREPFSGVGKPEPLKHALAGYWSRRITDEHRMVYKVADDALWIVQL
KYHY

Download         Length: 255 bp

>T139044 NZ_CP058342:2719322-2719429 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9244.40 Da        Isoelectric Point: 4.7769

>AT139044 WP_032492621.1 NZ_CP043575:c566809-566558 [Comamonas koreensis]
MDAITYTHARANLAGTMDRVCNDHEPVIITRNGDQSVVILSLEDFQALEETAYLLRSPANAKRLFKSIEQLEAGRGQARE
LAE

Download         Length: 252 bp

>AT139044 NZ_CP058342:c2719275-2719209 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1V0BEH9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1V0BEH6

References