Detailed information of TA system TA139039

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2863057..2863658
• Replicon: chromosome
• Accession: NZ_CP043573
• Organism: Comamonas testosteroni strain R5-28

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: F0Q02_RS13065
• Protein ID: WP_003055100.1
• Coordinates: 2863057..2863443 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B7WTR2
• Locus tag: F0Q02_RS13070
• Protein ID: WP_003055097.1
• Coordinates: 2863443..2863658 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0Q02_RS13040	2858466..2858831	+	366	WP_001277463.1	mercury resistance co-regulator MerD	-
F0Q02_RS13045	2858828..2859064	+	237	WP_003055146.1	broad-spectrum mercury transporter MerE	-
F0Q02_RS13050	2859130..2859342	+	213	WP_000993245.1	DUF3330 domain-containing protein	-
F0Q02_RS13055	2859472..2860032	+	561	WP_003055107.1	recombinase family protein	-
F0Q02_RS13060	2860035..2863004	+	2970	WP_003055103.1	Tn3 family transposase	-
F0Q02_RS13065	2863057..2863443	-	387	WP_003055100.1	type II toxin-antitoxin system VapC family toxin	Toxin
F0Q02_RS13070	2863443..2863658	-	216	WP_003055097.1	DUF2191 domain-containing protein	Antitoxin
F0Q02_RS13075	2863744..2864568	+	825	WP_003055094.1	SprT-like domain-containing protein	-
F0Q02_RS13080	2864883..2867333	-	2451	WP_080553891.1	cadmium-translocating P-type ATPase	-
F0Q02_RS13085	2867685..2868611	-	927	WP_034398829.1	copper homeostasis membrane protein CopD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2816438..3171341	354903

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 13816.18 Da
• Isoelectric Point: 5.9593

>T139039 WP_003055100.1 NZ_CP043573:c2863443-2863057 [Comamonas testosteroni]
MPVSVLVDTSVWVRHFREADIHLQELLLQDSVLMHPMVHAELACGTPPAPRADTLAALAMLRPSQEASIPETLAFLEKNK
LFGKGCGLVDLSLLASTLITPGALLWTADRRLAELAAQLGVAYAIPTH

Nucleotide

• Length: 387 bp

>T139039 NZ_CP058342:1862732-1862986 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7448.46 Da
• Isoelectric Point: 6.2846

>AT139039 WP_003055097.1 NZ_CP043573:c2863658-2863443 [Comamonas testosteroni]
MRSTFTIDDEVVNRARAVAAPGIAVPELVRLALETFTRVEAGKRLAALGGSAPDMPDVPRRGSAAEAEGSR

Nucleotide

• Length: 216 bp

>AT139039 NZ_CP043573:c2863658-2863443 [Comamonas testosteroni]
ATGAGATCGACCTTTACGATCGACGACGAAGTCGTGAACCGTGCCCGCGCTGTTGCAGCGCCCGGTATTGCTGTGCCTGA
ACTGGTACGCCTGGCACTTGAGACCTTCACTCGCGTCGAGGCAGGCAAGCGCTTGGCTGCCCTGGGCGGAAGCGCGCCAG
ACATGCCTGACGTGCCACGCCGTGGCAGCGCGGCAGAGGCAGAAGGCTCTCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A4Y8TDR8