Detailed information of TA system TA139036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 438938..439578
• Replicon: chromosome
• Accession: NZ_CP043571
• Organism: Pseudomonas migulae strain R1-9

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: F0Q00_RS01920
• Protein ID: WP_182343081.1
• Coordinates: 438938..439120 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: F0Q00_RS01925
• Protein ID: WP_095167490.1
• Coordinates: 439177..439578 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0Q00_RS01905	435064..435990	+	927	WP_182343077.1	serine acetyltransferase	-
F0Q00_RS01910	436408..438369	+	1962	WP_166590325.1	choline transporter BetT	-
F0Q00_RS01915	438385..438642	-	258	WP_182343079.1	hypothetical protein	-
F0Q00_RS01920	438938..439120	+	183	WP_182343081.1	type II toxin-antitoxin system HicA family toxin	Toxin
F0Q00_RS01925	439177..439578	+	402	WP_095167490.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
F0Q00_RS01930	439634..440470	-	837	WP_166590285.1	taurine dioxygenase	-
F0Q00_RS01935	440515..441354	-	840	WP_182343083.1	taurine ABC transporter permease TauC	-
F0Q00_RS01940	441351..442145	-	795	WP_166590287.1	taurine ABC transporter ATP-binding subunit	-
F0Q00_RS01945	442161..443138	-	978	WP_182344640.1	taurine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6995.12 Da
• Isoelectric Point: 10.7459

>T139036 WP_182343081.1 NZ_CP043571:438938-439120 [Pseudomonas migulae]
MRSREMIRMIEEDGWYWVATKGSHHQYKHPRKPGRVTIKHPDADLPKGTINSILKQAGLK

Nucleotide

• Length: 183 bp

>T139036 NZ_CP058342:933243-933650 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14689.47 Da
• Isoelectric Point: 4.4720

>AT139036 WP_095167490.1 NZ_CP043571:439177-439578 [Pseudomonas migulae]
MKFPVVLHKDPDSDYGVIIPDVGGCFSAGETVAQALDNVKEALALHYEGLVADGDPLPQVHEIDQHFQNPDYAGGIWAVV
EFDVTPYFGKSVRFNATLPEQLLERIDQTVRRDQRYSSRSGFLAAAALRELSV

Nucleotide

• Length: 402 bp

>AT139036 NZ_CP058342:932996-933262 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA