Detailed information of TA system TA139034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 5738351..5740041
• Replicon: chromosome
• Accession: NZ_CP043568
• Organism: Comamonas testosteroni strain T5-67

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: F0P97_RS26440
• Protein ID: WP_182284981.1
• Coordinates: 5739163..5740041 (-)
• Length: 293 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: F0P97_RS26435
• Protein ID: WP_182284980.1
• Coordinates: 5738351..5739157 (-)
• Length: 269 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0P97_RS26415	5734348..5735124	-	777	WP_182284976.1	SDR family oxidoreductase	-
F0P97_RS26420	5735441..5736199	-	759	WP_182284977.1	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	-
F0P97_RS26425	5736330..5737316	-	987	WP_182284978.1	tripartite tricarboxylate transporter substrate binding protein	-
F0P97_RS26430	5737508..5738308	-	801	WP_182284979.1	aspartate dehydrogenase	-
F0P97_RS26435	5738351..5739157	-	807	WP_182284980.1	IclR family transcriptional regulator	Antitoxin
F0P97_RS26440	5739163..5740041	-	879	WP_182284981.1	alpha/beta hydrolase	Toxin
F0P97_RS26445	5740050..5740583	-	534	WP_003072476.1	cupin domain-containing protein	-
F0P97_RS26450	5740844..5742520	-	1677	WP_182284982.1	long-chain-fatty-acid--CoA ligase	-
F0P97_RS26455	5742734..5743798	-	1065	WP_182284983.1	fructose-bisphosphate aldolase class II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (44-277)

Antitoxin

• Transcription regulator IclR, C-terminal (137-257)

Sequences

Toxin

Protein

• Length: 293 a.a.
• Molecular weight: 30664.19 Da
• Isoelectric Point: 6.3787

>T139034 WP_182284981.1 NZ_CP043568:c5740041-5739163 [Comamonas testosteroni]
MHEDLLSLKLQLLQTGFPERLVKLPQKAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLAQSAPADADYAQALAQSLLVLGVRRCILVGHSLGALMAARLAAMAAPGLVEQLVLISPAGGYGATAKAEQQAKVRE
GRLASLAEKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQAQGRLGMPVEVWVGEHDVV
TTPAACKSWSELLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS

Nucleotide

• Length: 879 bp

>T139034 NZ_CP058342:722277-722573 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 269 a.a.
• Molecular weight: 29313.27 Da
• Isoelectric Point: 5.1709

>AT139034 WP_182284980.1 NZ_CP043568:c5739157-5738351 [Comamonas testosteroni]
MSETPEISTNEQDRYTVPALDRGLRLLACFGPEQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGRVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR

Nucleotide

• Length: 807 bp

>AT139034 NZ_CP058342:722575-722970 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA