Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 3859239..3859857 Replicon chromosome
Accession NZ_CP043568
Organism Comamonas testosteroni strain T5-67

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag F0P97_RS17855 Protein ID WP_182283350.1
Coordinates 3859561..3859857 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag F0P97_RS17850 Protein ID WP_182283349.1
Coordinates 3859239..3859556 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0P97_RS17825 3854313..3854708 - 396 WP_182287235.1 helix-turn-helix domain-containing protein -
F0P97_RS17830 3854828..3855931 + 1104 WP_182287236.1 hypothetical protein -
F0P97_RS17835 3856044..3856850 + 807 WP_182283348.1 alpha/beta hydrolase -
F0P97_RS17840 3856965..3858131 + 1167 WP_182287237.1 serine hydrolase -
F0P97_RS17845 3858155..3859183 + 1029 WP_182287238.1 dienelactone hydrolase family protein -
F0P97_RS17850 3859239..3859556 - 318 WP_182283349.1 putative addiction module antidote protein Antitoxin
F0P97_RS17855 3859561..3859857 - 297 WP_182283350.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0P97_RS17860 3860065..3861189 - 1125 WP_182283351.1 hypothetical protein -
F0P97_RS17865 3861357..3862298 - 942 WP_182283352.1 AAA family ATPase -
F0P97_RS17870 3862403..3862690 - 288 WP_182283353.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul1 / qacE / cmlA1 / aadA2 / blaCARB-2 / dfrA16 / tet(C) - 3830830..3873491 42661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(11-99)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10702.34 Da        Isoelectric Point: 9.7118

>T139033 WP_182283350.1 NZ_CP043568:c3859857-3859561 [Comamonas testosteroni]
MIQVLRTAAFDGWLQALRDKVGQRQVLARLTRLSLGNWGDCKPVGGEVTELRIDSGPGYRVYCWRDGDVVVVALGGGDKS
TQQKDIAKAQAMVKDLKG

Download         Length: 297 bp

>T139033 NZ_CP058342:655570-655884 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11322.92 Da        Isoelectric Point: 5.0619

>AT139033 WP_182283349.1 NZ_CP043568:c3859556-3859239 [Comamonas testosteroni]
MNRATYEKLGIKPFDAAEYLQSDEDCAAYLQACLEQAPDDASVFAKALGDIARARGMMQLAKDTGLTREGLYKSLGEQGN
PSLSTVMKVMHALGLQMHIGPQTSA

Download         Length: 318 bp

>AT139033 NZ_CP058342:655881-656297 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References