139008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1053129..1053657 Replicon chromosome
Accession NZ_CP043556
Organism Vibrio cholerae strain RFB16

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag F0316_RS19365 Protein ID WP_000221352.1
Coordinates 1053129..1053419 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag F0316_RS19370 Protein ID WP_000213183.1
Coordinates 1053409..1053657 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0316_RS19305 1048454..1048720 + 267 WP_088132343.1 TIGR03643 family protein -
F0316_RS19315 1048838..1049155 - 318 WP_000077449.1 CcdB family protein -
F0316_RS19320 1049155..1049400 - 246 WP_001260801.1 type II toxin-antitoxin system CcdA family antitoxin -
F0316_RS19325 1049620..1050033 + 414 WP_149560848.1 GNAT family N-acetyltransferase -
F0316_RS19330 1050213..1050638 + 426 WP_000620001.1 N-acetyltransferase -
F0316_RS19340 1050960..1051112 + 153 WP_080285828.1 DUF645 family protein -
F0316_RS19345 1051364..1051621 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
F0316_RS19350 1051609..1051911 + 303 WP_000807826.1 type II toxin-antitoxin system RelE/ParE family toxin -
F0316_RS19355 1052078..1052545 + 468 WP_065818801.1 hypothetical protein -
F0316_RS19360 1052688..1052984 + 297 WP_148520498.1 Dabb family protein -
F0316_RS19365 1053129..1053419 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0316_RS19370 1053409..1053657 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F0316_RS19375 1053852..1054451 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
F0316_RS19380 1054669..1054953 + 285 WP_149560850.1 nuclear transport factor 2 family protein -
F0316_RS19390 1055166..1055579 + 414 WP_148523205.1 VOC family protein -
F0316_RS19400 1055728..1056120 + 393 WP_001085000.1 nuclear transport factor 2 family protein -
F0316_RS19405 1056256..1056792 + 537 WP_019829641.1 nucleotidyltransferase family protein -
F0316_RS19410 1056933..1057721 + 789 WP_142578780.1 DUF2971 domain-containing protein -
F0316_RS19415 1057870..1058402 + 533 Protein_983 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1058597..1059517 920
- inside Integron - - 981561..1071623 90062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T139008 WP_000221352.1 NZ_CP043556:c1053419-1053129 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T139008 NZ_CP043556:c1053419-1053129 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTACCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT139008 WP_000213183.1 NZ_CP043556:c1053657-1053409 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT139008 NZ_CP058327:c89609-89379 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References