Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 1051364..1051911 Replicon chromosome
Accession NZ_CP043556
Organism Vibrio cholerae strain RFB16

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3AD26
Locus tag F0316_RS19350 Protein ID WP_000807826.1
Coordinates 1051609..1051911 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag F0316_RS19345 Protein ID WP_000861987.1
Coordinates 1051364..1051621 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0316_RS19290 1046965..1047246 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
F0316_RS19295 1047243..1047530 + 288 WP_000869995.1 type II toxin-antitoxin system RelE/ParE family toxin -
F0316_RS19300 1047680..1048258 + 579 WP_172626090.1 DJ-1/PfpI family protein -
F0316_RS19305 1048454..1048720 + 267 WP_088132343.1 TIGR03643 family protein -
F0316_RS19315 1048838..1049155 - 318 WP_000077449.1 CcdB family protein -
F0316_RS19320 1049155..1049400 - 246 WP_001260801.1 type II toxin-antitoxin system CcdA family antitoxin -
F0316_RS19325 1049620..1050033 + 414 WP_149560848.1 GNAT family N-acetyltransferase -
F0316_RS19330 1050213..1050638 + 426 WP_000620001.1 N-acetyltransferase -
F0316_RS19340 1050960..1051112 + 153 WP_080285828.1 DUF645 family protein -
F0316_RS19345 1051364..1051621 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F0316_RS19350 1051609..1051911 + 303 WP_000807826.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0316_RS19355 1052078..1052545 + 468 WP_065818801.1 hypothetical protein -
F0316_RS19360 1052688..1052984 + 297 WP_148520498.1 Dabb family protein -
F0316_RS19365 1053129..1053419 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin -
F0316_RS19370 1053409..1053657 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
F0316_RS19375 1053852..1054451 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
F0316_RS19380 1054669..1054953 + 285 WP_149560850.1 nuclear transport factor 2 family protein -
F0316_RS19390 1055166..1055579 + 414 WP_148523205.1 VOC family protein -
F0316_RS19400 1055728..1056120 + 393 WP_001085000.1 nuclear transport factor 2 family protein -
F0316_RS19405 1056256..1056792 + 537 WP_019829641.1 nucleotidyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 981561..1071623 90062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11725.65 Da        Isoelectric Point: 5.1972

>T139007 WP_000807826.1 NZ_CP043556:1051609-1051911 [Vibrio cholerae]
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPLELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T139007 NZ_CP058326:53921-54403 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT139007 WP_000861987.1 NZ_CP043556:1051364-1051621 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT139007 NZ_CP058326:53667-53933 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AD26

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References