Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-Phd |
Location | 1051364..1051911 | Replicon | chromosome |
Accession | NZ_CP043556 | ||
Organism | Vibrio cholerae strain RFB16 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0H3AD26 |
Locus tag | F0316_RS19350 | Protein ID | WP_000807826.1 |
Coordinates | 1051609..1051911 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9KM93 |
Locus tag | F0316_RS19345 | Protein ID | WP_000861987.1 |
Coordinates | 1051364..1051621 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F0316_RS19290 | 1046965..1047246 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
F0316_RS19295 | 1047243..1047530 | + | 288 | WP_000869995.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
F0316_RS19300 | 1047680..1048258 | + | 579 | WP_172626090.1 | DJ-1/PfpI family protein | - |
F0316_RS19305 | 1048454..1048720 | + | 267 | WP_088132343.1 | TIGR03643 family protein | - |
F0316_RS19315 | 1048838..1049155 | - | 318 | WP_000077449.1 | CcdB family protein | - |
F0316_RS19320 | 1049155..1049400 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
F0316_RS19325 | 1049620..1050033 | + | 414 | WP_149560848.1 | GNAT family N-acetyltransferase | - |
F0316_RS19330 | 1050213..1050638 | + | 426 | WP_000620001.1 | N-acetyltransferase | - |
F0316_RS19340 | 1050960..1051112 | + | 153 | WP_080285828.1 | DUF645 family protein | - |
F0316_RS19345 | 1051364..1051621 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
F0316_RS19350 | 1051609..1051911 | + | 303 | WP_000807826.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
F0316_RS19355 | 1052078..1052545 | + | 468 | WP_065818801.1 | hypothetical protein | - |
F0316_RS19360 | 1052688..1052984 | + | 297 | WP_148520498.1 | Dabb family protein | - |
F0316_RS19365 | 1053129..1053419 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
F0316_RS19370 | 1053409..1053657 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
F0316_RS19375 | 1053852..1054451 | + | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
F0316_RS19380 | 1054669..1054953 | + | 285 | WP_149560850.1 | nuclear transport factor 2 family protein | - |
F0316_RS19390 | 1055166..1055579 | + | 414 | WP_148523205.1 | VOC family protein | - |
F0316_RS19400 | 1055728..1056120 | + | 393 | WP_001085000.1 | nuclear transport factor 2 family protein | - |
F0316_RS19405 | 1056256..1056792 | + | 537 | WP_019829641.1 | nucleotidyltransferase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integron | - | - | 981561..1071623 | 90062 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11725.65 Da Isoelectric Point: 5.1972
>T139007 WP_000807826.1 NZ_CP043556:1051609-1051911 [Vibrio cholerae]
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPLELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPLELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T139007 NZ_CP058326:53921-54403 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT139007 WP_000861987.1 NZ_CP043556:1051364-1051621 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT139007 NZ_CP058326:53667-53933 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3AD26 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1T4SLM9 |