Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1046965..1047530 Replicon chromosome
Accession NZ_CP043556
Organism Vibrio cholerae strain RFB16

Toxin (Protein)


Gene name relE Uniprot ID A0A655YJZ8
Locus tag F0316_RS19295 Protein ID WP_000869995.1
Coordinates 1047243..1047530 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag F0316_RS19290 Protein ID WP_000086649.1
Coordinates 1046965..1047246 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0316_RS19240 1042268..1043185 + 918 WP_142735514.1 alpha/beta hydrolase -
F0316_RS19245 1043248..1043331 + 84 WP_149560880.1 acetyltransferase -
F0316_RS19250 1043338..1043934 + 597 WP_084981911.1 class I SAM-dependent methyltransferase -
F0316_RS19255 1043904..1044041 + 138 WP_094182966.1 DUF3265 domain-containing protein -
F0316_RS19260 1044400..1044522 + 123 WP_130249766.1 DUF3265 domain-containing protein -
F0316_RS19265 1044696..1044878 + 183 WP_088132376.1 DUF645 family protein -
F0316_RS19270 1045269..1045598 + 330 WP_080281738.1 GNAT family N-acetyltransferase -
F0316_RS19275 1045893..1046075 + 183 WP_000947517.1 DUF645 family protein -
F0316_RS19285 1046277..1046765 + 489 WP_000424240.1 hypothetical protein -
F0316_RS19290 1046965..1047246 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F0316_RS19295 1047243..1047530 + 288 WP_000869995.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0316_RS19300 1047680..1048258 + 579 WP_172626090.1 DJ-1/PfpI family protein -
F0316_RS19305 1048454..1048720 + 267 WP_088132343.1 TIGR03643 family protein -
F0316_RS19315 1048838..1049155 - 318 WP_000077449.1 CcdB family protein -
F0316_RS19320 1049155..1049400 - 246 WP_001260801.1 type II toxin-antitoxin system CcdA family antitoxin -
F0316_RS19325 1049620..1050033 + 414 WP_149560848.1 GNAT family N-acetyltransferase -
F0316_RS19330 1050213..1050638 + 426 WP_000620001.1 N-acetyltransferase -
F0316_RS19340 1050960..1051112 + 153 WP_080285828.1 DUF645 family protein -
F0316_RS19345 1051364..1051621 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
F0316_RS19350 1051609..1051911 + 303 WP_000807826.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 981561..1071623 90062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11031.76 Da        Isoelectric Point: 6.0710

>T139006 WP_000869995.1 NZ_CP043556:1047243-1047530 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSFSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T139006 NZ_CP058325:c5263584-5263201 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT139006 WP_000086649.1 NZ_CP043556:1046965-1047246 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT139006 NZ_CP058325:c5263826-5263584 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A655YJZ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References