Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 1046965..1047530 | Replicon | chromosome |
| Accession | NZ_CP043556 | ||
| Organism | Vibrio cholerae strain RFB16 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A655YJZ8 |
| Locus tag | F0316_RS19295 | Protein ID | WP_000869995.1 |
| Coordinates | 1047243..1047530 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | F0316_RS19290 | Protein ID | WP_000086649.1 |
| Coordinates | 1046965..1047246 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F0316_RS19240 | 1042268..1043185 | + | 918 | WP_142735514.1 | alpha/beta hydrolase | - |
| F0316_RS19245 | 1043248..1043331 | + | 84 | WP_149560880.1 | acetyltransferase | - |
| F0316_RS19250 | 1043338..1043934 | + | 597 | WP_084981911.1 | class I SAM-dependent methyltransferase | - |
| F0316_RS19255 | 1043904..1044041 | + | 138 | WP_094182966.1 | DUF3265 domain-containing protein | - |
| F0316_RS19260 | 1044400..1044522 | + | 123 | WP_130249766.1 | DUF3265 domain-containing protein | - |
| F0316_RS19265 | 1044696..1044878 | + | 183 | WP_088132376.1 | DUF645 family protein | - |
| F0316_RS19270 | 1045269..1045598 | + | 330 | WP_080281738.1 | GNAT family N-acetyltransferase | - |
| F0316_RS19275 | 1045893..1046075 | + | 183 | WP_000947517.1 | DUF645 family protein | - |
| F0316_RS19285 | 1046277..1046765 | + | 489 | WP_000424240.1 | hypothetical protein | - |
| F0316_RS19290 | 1046965..1047246 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| F0316_RS19295 | 1047243..1047530 | + | 288 | WP_000869995.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| F0316_RS19300 | 1047680..1048258 | + | 579 | WP_172626090.1 | DJ-1/PfpI family protein | - |
| F0316_RS19305 | 1048454..1048720 | + | 267 | WP_088132343.1 | TIGR03643 family protein | - |
| F0316_RS19315 | 1048838..1049155 | - | 318 | WP_000077449.1 | CcdB family protein | - |
| F0316_RS19320 | 1049155..1049400 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| F0316_RS19325 | 1049620..1050033 | + | 414 | WP_149560848.1 | GNAT family N-acetyltransferase | - |
| F0316_RS19330 | 1050213..1050638 | + | 426 | WP_000620001.1 | N-acetyltransferase | - |
| F0316_RS19340 | 1050960..1051112 | + | 153 | WP_080285828.1 | DUF645 family protein | - |
| F0316_RS19345 | 1051364..1051621 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| F0316_RS19350 | 1051609..1051911 | + | 303 | WP_000807826.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 981561..1071623 | 90062 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11031.76 Da Isoelectric Point: 6.0710
>T139006 WP_000869995.1 NZ_CP043556:1047243-1047530 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSFSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSFSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T139006 NZ_CP058325:c5263584-5263201 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT139006 WP_000086649.1 NZ_CP043556:1046965-1047246 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT139006 NZ_CP058325:c5263826-5263584 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A655YJZ8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |