Detailed information of TA system TA139005

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1034109..1034668
• Replicon: chromosome
• Accession: NZ_CP043556
• Organism: Vibrio cholerae strain RFB16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D7HHK2
• Locus tag: F0316_RS19150
• Protein ID: WP_000578471.1
• Coordinates: 1034109..1034387 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: F0316_RS19155
• Protein ID: WP_000381183.1
• Coordinates: 1034384..1034668 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0316_RS19105	1029623..1029804	+	182	Protein_933	DUF645 family protein	-
F0316_RS19115	1030002..1030427	+	426	WP_149560839.1	hypothetical protein	-
F0316_RS19120	1030527..1030775	+	249	Protein_935	DUF3709 domain-containing protein	-
F0316_RS19125	1031045..1031521	+	477	WP_001047183.1	GNAT family N-acetyltransferase	-
F0316_RS19135	1031640..1032155	+	516	WP_000090010.1	hypothetical protein	-
F0316_RS19140	1032293..1032637	+	345	Protein_938	hypothetical protein	-
F0316_RS19145	1032697..1033737	-	1041	WP_057569038.1	IS481 family transposase	-
F0316_RS19150	1034109..1034387	-	279	WP_000578471.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
F0316_RS19155	1034384..1034668	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
F0316_RS19160	1035181..1035306	+	126	Protein_942	DUF3265 domain-containing protein	-
F0316_RS19165	1035540..1035674	+	135	WP_080299877.1	DUF645 family protein	-
F0316_RS19175	1035893..1036306	+	414	WP_149560841.1	GNAT family N-acetyltransferase	-
F0316_RS19180	1036466..1037044	+	579	WP_149560842.1	O-methyltransferase	-
F0316_RS19185	1037196..1037897	+	702	WP_001175917.1	hypothetical protein	-
F0316_RS19190	1038092..1038982	+	891	WP_114721400.1	bacteriophage abortive infection AbiH family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1032697..1033737	1040
	-	inside	Integron	-	-	981561..1071623	90062

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10838.56 Da
• Isoelectric Point: 4.6794

>T139005 WP_000578471.1 NZ_CP043556:c1034387-1034109 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T139005 NZ_CP043556:c1034387-1034109 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT139005 WP_000381183.1 NZ_CP043556:c1034668-1034384 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT139005 NZ_CP058325:c4964534-4964313 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A271VKS2

Antitoxin

• AlphaFold DB: A0A067BL33