Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 979646..980227 Replicon chromosome
Accession NZ_CP043556
Organism Vibrio cholerae strain RFB16

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag F0316_RS18615 Protein ID WP_172626086.1
Coordinates 979907..980227 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag F0316_RS18610 Protein ID WP_000557292.1
Coordinates 979646..979888 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0316_RS18565 975227..975463 - 237 WP_059261233.1 DUF3709 domain-containing protein -
F0316_RS18570 975481..975675 - 195 Protein_847 DUF3709 domain-containing protein -
F0316_RS18575 975863..976096 - 234 WP_042990080.1 DUF3709 domain-containing protein -
F0316_RS18580 976392..976634 - 243 WP_149560818.1 hypothetical protein -
F0316_RS18585 976841..977206 - 366 WP_000969534.1 hypothetical protein -
F0316_RS18590 977349..977984 - 636 WP_095474051.1 hypothetical protein -
F0316_RS18595 978266..978493 - 228 WP_172626103.1 DUF3709 domain-containing protein -
F0316_RS18605 978604..979407 - 804 WP_149560819.1 hypothetical protein -
F0316_RS18610 979646..979888 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F0316_RS18615 979907..980227 + 321 WP_172626086.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0316_RS18620 980341..981381 - 1041 WP_057569038.1 IS481 family transposase -
F0316_RS18625 981561..982025 - 465 WP_057563740.1 hypothetical protein -
F0316_RS19915 982586..982696 + 111 Protein_858 DUF645 family protein -
F0316_RS18640 983025..983246 + 222 WP_033839066.1 DUF3709 domain-containing protein -
F0316_RS18650 983542..983928 + 387 WP_000703159.1 VOC family protein -
F0316_RS18655 984066..984566 + 501 WP_000686370.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 980341..981381 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12157.97 Da        Isoelectric Point: 8.2556

>T139001 WP_172626086.1 NZ_CP043556:979907-980227 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
CILIVAVLGQSQLPQKHLKCTNSDLI

Download         Length: 321 bp

>T139001 NZ_CP058325:c3334240-3334138 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT139001 WP_000557292.1 NZ_CP043556:979646-979888 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT139001 NZ_CP058325:3334131-3334276 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References