139000

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 967834..968372 Replicon chromosome
Accession NZ_CP043556
Organism Vibrio cholerae strain RFB16

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag F0316_RS18490 Protein ID WP_000802136.1
Coordinates 968073..968372 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag F0316_RS18485 Protein ID WP_001107719.1
Coordinates 967834..968076 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0316_RS18435 962837..963190 - 354 WP_172626102.1 nuclear transport factor 2 family protein -
F0316_RS18440 963425..963604 - 180 WP_149560812.1 DUF645 family protein -
F0316_RS18450 963900..964292 - 393 WP_055052334.1 nuclear transport factor 2 family protein -
F0316_RS18455 964443..965096 - 654 WP_057573342.1 hypothetical protein -
F0316_RS18460 965249..965611 - 363 WP_172626085.1 DUF4144 domain-containing protein -
F0316_RS18465 965722..966138 - 417 WP_027694820.1 DUF1311 domain-containing protein -
F0316_RS18475 966299..966898 - 600 WP_000777735.1 porin family protein -
F0316_RS18480 967066..967623 - 558 WP_149560813.1 hypothetical protein -
F0316_RS18485 967834..968076 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
F0316_RS18490 968073..968372 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0316_RS18500 968489..969022 - 534 WP_055035881.1 GNAT family N-acetyltransferase -
F0316_RS18510 969249..969701 + 453 WP_000024294.1 DUF2384 domain-containing protein -
F0316_RS18515 969701..970171 + 471 WP_000784954.1 RES family NAD+ phosphorylase -
F0316_RS18520 970195..970311 - 117 WP_080387445.1 DUF3265 domain-containing protein -
F0316_RS18525 970313..970765 - 453 WP_032469029.1 hypothetical protein -
F0316_RS18530 970917..971192 - 276 WP_032473764.1 hypothetical protein -
F0316_RS18535 971401..971583 - 183 WP_149560814.1 DUF645 family protein -
F0316_RS18545 971877..972632 - 756 WP_149560816.1 FRG domain-containing protein -
F0316_RS18550 972707..972991 - 285 WP_119781300.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 963900..974010 10110
- inside Integron - - 957478..979888 22410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T139000 WP_000802136.1 NZ_CP043556:968073-968372 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T139000 NZ_CP058325:2606501-2607823 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT139000 WP_001107719.1 NZ_CP043556:967834-968076 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT139000 NZ_CP058325:2606235-2606501 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References