Detailed information of TA system TA138999

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2114530..2116355
• Replicon: chromosome
• Accession: NZ_CP043554
• Organism: Vibrio cholerae strain RFB16

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: F0316_RS09825
• Protein ID: WP_172626009.1
• Coordinates: 2114530..2115891 (+)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: F0316_RS09830
• Protein ID: WP_000804848.1
• Coordinates: 2115888..2116355 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0316_RS09790	2110062..2111726	+	1665	WP_149560452.1	DNA repair protein RecN	-
F0316_RS09795	2111885..2112244	+	360	WP_001160912.1	outer membrane protein assembly factor BamE	-
F0316_RS09800	2112322..2112627	-	306	WP_001918351.1	RnfH family protein	-
F0316_RS09805	2112630..2113064	-	435	WP_000815880.1	type II toxin-antitoxin system RatA family toxin	-
F0316_RS09810	2113248..2113733	+	486	WP_000162689.1	SsrA-binding protein SmpB	-
F0316_RS09825	2114530..2115891	+	1362	WP_172626009.1	HipA domain-containing protein	Toxin
F0316_RS09830	2115888..2116355	+	468	WP_000804848.1	helix-turn-helix domain-containing protein	Antitoxin
F0316_RS09835	2116783..2117361	+	579	WP_000109982.1	class I SAM-dependent methyltransferase	-
F0316_RS09840	2117365..2120316	+	2952	WP_172626010.1	DEAD/DEAH box helicase family protein	-
F0316_RS09845	2120381..2121331	+	951	WP_000635666.1	NERD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-383)

Antitoxin

• Cro/C1-type helix-turn-helix domain (80-138)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51299.23 Da
• Isoelectric Point: 4.8511

>T138999 WP_172626009.1 NZ_CP043554:2114530-2115891 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQYNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Nucleotide

• Length: 1362 bp

>T138999 NZ_CP058325:c1227343-1227125 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17048.54 Da
• Isoelectric Point: 10.7084

>AT138999 WP_000804848.1 NZ_CP043554:2115888-2116355 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKSATHSSKEQTPLDTPTRSKASKNVKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Nucleotide

• Length: 468 bp

>AT138999 NZ_CP058325:c1227744-1227370 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG