Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3913546..3915235 Replicon chromosome
Accession NZ_CP043542
Organism Escherichia coli strain F2_81

Toxin (Protein)


Gene name mosT Uniprot ID A0A8S7CPU8
Locus tag CPH39_RS18925 Protein ID WP_053884070.1
Coordinates 3913546..3914466 (-) Length 307 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag CPH39_RS18930 Protein ID WP_064763319.1
Coordinates 3914453..3915235 (-) Length 261 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPH39_RS18905 (3909390) 3909390..3910274 + 885 WP_001119037.1 LysR family transcriptional regulator -
CPH39_RS18910 (3910977) 3910977..3911255 - 279 WP_024227134.1 hypothetical protein -
CPH39_RS18915 (3911421) 3911421..3912143 - 723 WP_053884074.1 SDR family oxidoreductase -
CPH39_RS18920 (3912242) 3912242..3913141 + 900 WP_053884073.1 LysR family transcriptional regulator -
CPH39_RS18925 (3913546) 3913546..3914466 - 921 WP_053884070.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CPH39_RS18930 (3914453) 3914453..3915235 - 783 WP_064763319.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
CPH39_RS18935 (3915551) 3915551..3918760 + 3210 WP_053884066.1 RNA-directed DNA polymerase -
CPH39_RS18940 (3918967) 3918967..3919125 + 159 WP_096220653.1 ash family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3912242..3983725 71483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-261)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(3-90)


Sequences

Toxin        


Download         Length: 307 a.a.        Molecular weight: 34579.93 Da        Isoelectric Point: 6.9552

>T138990 WP_053884070.1 NZ_CP043542:c3914466-3913546 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNSK
PGITAIRQENKADEKRIIVNTADAQIKIEVSPVWRGLLLPPAEMSVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKNKNPAKYVAAVNKLERVLE

Download         Length: 921 bp

>T138990 NZ_CP058321:982716-983234 [Halomonas sp. SH5A2]
ATGATTGTACTGCCAGCGCTAAATACTCAGGCCTATCGTGTGCATGTCCCAAAATGGGCATTCTCGCCCACTAGCGGTGC
TGGAGCGAGAGAGCATGGTGGTCGATTAAACCGCCCCGGCGTGGCTGCTTTATATTTGGCGCTTGATGATCAAACAGCGT
TGGCCGAGTACAAGCAGCTGTCTGCCTTGATGCCGTCAGGCCTAATCGTCAGCTATACAATAAGCGTTACTCAGCTTGTC
GATTTTCGTAACGGTTATAGCATGCAATGGGACTCCCTCTGGCAGGAGCTTTATTGCGACTGGCGCAAGCTTTGGTTCAA
TGAACGTATTGAGCCACCGAGCTGGCTATTAGGCGATATGGCATTAGCACAAGGGGCAAAAGGCGTTCTGTTTCCTTCTT
TGGCAAACCCGTCAGGTATGAACCTTGTGCTCTATACCGATAATCTGGCAGAAAGTGATTTATTAGAAGCCTACGATCCG
CACGGTGATCTGCCTCGTGACGCACGCTCCTGGGAGTAA

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29098.35 Da        Isoelectric Point: 8.1216

>AT138990 WP_064763319.1 NZ_CP043542:c3915235-3914453 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTCNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTSFITELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Download         Length: 783 bp

>AT138990 NZ_CP043542:c3915235-3914453 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCTGCAACGG
CATAGATCGTAAGCTTTCTTACCTCTATGTCCAGAATGGCTGGCTTCGGCGGATCGCTCACGGCGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTGCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTCCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTTGAACAATCTGCAACGTTTATCACGCTGTATACATCGGGCCTTACTGTTGATGTAA
CGTCATTTATCACGGAGCTTAAAATTGGCGACCGCCAGTTAGCAGGCAGTGCTCCGGAACTGGCCGCGTATGAGATTGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCGTTGTTTCAGGGATTGAATCTTCTCAGCCCGCGTAAATT
GCAGGCACTGCTTCGCGCCAGCCATTCAGTTAAAACCAACCGGGTGATGCTTTATCTTGCCCGACGCAATGGGCACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCCGGCGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCACGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References