Detailed information of TA system TA138988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 3064908..3065386
• Replicon: chromosome
• Accession: NZ_CP043542
• Organism: Escherichia coli strain F2_81

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: CPH39_RS14965
• Protein ID: WP_001303876.1
• Coordinates: 3065099..3065386 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: CPH39_RS14960
• Protein ID: WP_000536233.1
• Coordinates: 3064908..3065099 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPH39_RS14925 (3060288)	3060288..3061058	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
CPH39_RS14930 (3061140)	3061140..3061826	-	687	WP_000788749.1	ATP-binding protein	-
CPH39_RS14935 (3061833)	3061833..3062948	-	1116	WP_001205820.1	hypothetical protein	-
CPH39_RS14940 (3063027)	3063027..3063482	+	456	WP_000273724.1	hypothetical protein	-
CPH39_RS14945 (3063689)	3063689..3064114	-	426	WP_000693855.1	toxin YdaT family protein	-
CPH39_RS14950 (3064098)	3064098..3064370	-	273	WP_000887453.1	YdaS family helix-turn-helix protein	-
CPH39_RS14955 (3064479)	3064479..3064880	+	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
CPH39_RS14960 (3064908)	3064908..3065099	+	192	WP_000536233.1	hypothetical protein	Antitoxin
CPH39_RS14965 (3065099)	3065099..3065386	+	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CPH39_RS14970 (3065663)	3065663..3065818	+	156	WP_000379575.1	DUF1391 family protein	-
CPH39_RS26590 (3065820)	3065820..3065948	+	129	WP_000344963.1	protein YdfB	-
CPH39_RS14975 (3065960)	3065960..3066349	+	390	WP_000394511.1	hypothetical protein	-
CPH39_RS14980 (3066536)	3066536..3066721	-	186	WP_001133046.1	hypothetical protein	-
CPH39_RS14985 (3067295)	3067295..3067483	+	189	WP_000413705.1	cell division inhibition protein DicB	-
CPH39_RS14990 (3067480)	3067480..3067671	+	192	WP_001098307.1	DUF1482 family protein	-
CPH39_RS14995 (3067765)	3067765..3070236	+	2472	WP_000034468.1	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3022154..3078898	56744

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T138988 WP_001303876.1 NZ_CP043542:3065099-3065386 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T138988 NZ_CP058321:c813303-813004 [Halomonas sp. SH5A2]
ATGCCCACGTTTCATATCACACCTAGAGCGAGAGACGATTTAAAGAATATTGGCCGCTATACGGAGCGGCAATGGGGCAG
GAGCCAACGTAATATCTATCTAAAAGATTTTGAAAAACGATTTCACTGGCTCGCAGAAAATCCACTATTAGGAAAACATC
GCGCTGACATCAGCGAGGGTTATTACAGCTACCCACAAGGCCAGCATGTTATCTTTTACCTGATTGGCCAAGGGGGCATT
GAGATAATCGGCATTCCTCACAAAGAAGTGGATATCGTCTCGTATTTTCTGCCTGATTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT138988 WP_000536233.1 NZ_CP043542:3064908-3065099 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT138988 NZ_CP058321:c813551-813303 [Halomonas sp. SH5A2]
ATGGCGACGACAAGCCTTAGCCTCGGAGAGCACTGGGAAGTCTTCATCAGAAACGAGGTCTCCAGCGGTCGCTACGGCTC
CGCAAGTGAGGTTGTGCGTGACGCTTTGCGTGCCATGGAGGAACGCAAAAGCAAAATTGAAGCGCTACGTACTCATCTAG
CCCAAGGTGCCGAGCAAGCAAGGGCTGGTGAATTCGTGGATGATTTCTCGGTGGATTCACTAATCAACGATTTGGATAGA
GAAACGTGA