Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2426132..2427720 | Replicon | chromosome |
| Accession | NZ_CP043542 | ||
| Organism | Escherichia coli strain F2_81 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A0K4CD26 |
| Locus tag | CPH39_RS11840 | Protein ID | WP_001613069.1 |
| Coordinates | 2426398..2427720 (+) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | CPH39_RS11835 | Protein ID | WP_001613070.1 |
| Coordinates | 2426132..2426398 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPH39_RS11805 (2422561) | 2422561..2423475 | + | 915 | WP_053884479.1 | bestrophin family protein | - |
| CPH39_RS11810 (2423479) | 2423479..2424237 | - | 759 | WP_053884480.1 | trans-aconitate 2-methyltransferase | - |
| CPH39_RS11815 (2424294) | 2424294..2424584 | - | 291 | WP_000558527.1 | (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase | - |
| CPH39_RS11820 (2424608) | 2424608..2425483 | - | 876 | WP_000774165.1 | 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase | - |
| CPH39_RS11825 (2425510) | 2425510..2425701 | - | 192 | Protein_2325 | autoinducer 2 ABC transporter substrate-binding protein | - |
| CPH39_RS26560 (2425748) | 2425748..2425921 | + | 174 | WP_001014420.1 | autotransporter outer membrane beta-barrel domain-containing protein | - |
| CPH39_RS11835 (2426132) | 2426132..2426398 | + | 267 | WP_001613070.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| CPH39_RS11840 (2426398) | 2426398..2427720 | + | 1323 | WP_001613069.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
| CPH39_RS11845 (2427991) | 2427991..2428260 | + | 270 | Protein_2329 | AraC family transcriptional regulator | - |
| CPH39_RS11850 (2428694) | 2428694..2429257 | + | 564 | WP_096220629.1 | type 1 fimbrial major subunit FimA | - |
| CPH39_RS11855 (2429618) | 2429618..2430328 | + | 711 | WP_001195165.1 | fimbria/pilus periplasmic chaperone | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49334.97 Da Isoelectric Point: 8.5823
>T138985 WP_001613069.1 NZ_CP043542:2426398-2427720 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
Download Length: 1323 bp
>T138985 NZ_CP058315:c1245074-1244811 [Treponema parvum]
GTGAATACGAAGCAACAAAAGATATATTGCACAATCTTCAAAAATCCTGTCCAATCAAATATTAAGTGGCAGGATATTGA
AAATCTTTTAAAATCTTTAGGTGCTTCCATTTCAGAGGGAAATGGCTCTCGTGTACGAATAGAATTGAATGGAGAAAGAG
CTGTTTTTCATCGTCCGCATCCAGAAAAAATAACTGACAAAGGTGCTGTAAAATCTATGCGTAGATTTTTAGAAAACGCA
GGGGTGAAGAATGATGACTTATAA
GTGAATACGAAGCAACAAAAGATATATTGCACAATCTTCAAAAATCCTGTCCAATCAAATATTAAGTGGCAGGATATTGA
AAATCTTTTAAAATCTTTAGGTGCTTCCATTTCAGAGGGAAATGGCTCTCGTGTACGAATAGAATTGAATGGAGAAAGAG
CTGTTTTTCATCGTCCGCATCCAGAAAAAATAACTGACAAAGGTGCTGTAAAATCTATGCGTAGATTTTTAGAAAACGCA
GGGGTGAAGAATGATGACTTATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10033.36 Da Isoelectric Point: 4.9632
>AT138985 WP_001613070.1 NZ_CP043542:2426132-2426398 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW
Download Length: 267 bp
>AT138985 NZ_CP058315:c1244824-1244483 [Treponema parvum]
ATGATGACTTATAAAGGATTTATTGCAACTGTTGAATATGATGATGAAGCTCATGTATTTACTGGAGAGGTAATCAATAC
TCGTACTGTAATTACTTTTCAGGGAACGACTGTTGATGAGATGGAAAATGAATTTCGTGCTTCTGTTGATGATTATCTTG
AGTGGTGTAAGGAAGATGGAATTGAACCAGAAAAACCTTATTCAGGAAAATTCAATGTTCGTCTTTCTCCATTATTTCAT
AGCCAGGTTGCTCTTGCTGCAAAAAAATTGGATATGTCTTTGAATAGCTTTGTAGAAAAATCATTAAAGGATGAAATATC
GAATATGCAGTTGGTTTATTAG
ATGATGACTTATAAAGGATTTATTGCAACTGTTGAATATGATGATGAAGCTCATGTATTTACTGGAGAGGTAATCAATAC
TCGTACTGTAATTACTTTTCAGGGAACGACTGTTGATGAGATGGAAAATGAATTTCGTGCTTCTGTTGATGATTATCTTG
AGTGGTGTAAGGAAGATGGAATTGAACCAGAAAAACCTTATTCAGGAAAATTCAATGTTCGTCTTTCTCCATTATTTCAT
AGCCAGGTTGCTCTTGCTGCAAAAAAATTGGATATGTCTTTGAATAGCTTTGTAGAAAAATCATTAAAGGATGAAATATC
GAATATGCAGTTGGTTTATTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|