Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2382738..2383264 | Replicon | chromosome |
| Accession | NZ_CP043542 | ||
| Organism | Escherichia coli strain F2_81 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | CPH39_RS11535 | Protein ID | WP_000323025.1 |
| Coordinates | 2382977..2383264 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | CPH39_RS11530 | Protein ID | WP_000534858.1 |
| Coordinates | 2382738..2382977 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPH39_RS11500 (2377833) | 2377833..2378075 | + | 243 | Protein_2258 | DUF977 family protein | - |
| CPH39_RS11505 (2378072) | 2378072..2378561 | + | 490 | Protein_2259 | class I SAM-dependent methyltransferase | - |
| CPH39_RS11510 (2379039) | 2379039..2379460 | + | 422 | Protein_2260 | hypothetical protein | - |
| CPH39_RS26535 (2380095) | 2380095..2380466 | + | 372 | WP_001406656.1 | helix-turn-helix domain-containing protein | - |
| CPH39_RS26540 (2380504) | 2380504..2381166 | + | 663 | Protein_2262 | ISNCY family transposase | - |
| CPH39_RS26545 (2381287) | 2381287..2381436 | + | 150 | WP_011443592.1 | protein YdfW | - |
| CPH39_RS11520 (2381873) | 2381873..2382205 | - | 333 | WP_001349760.1 | FlxA-like family protein | - |
| CPH39_RS11525 (2382408) | 2382408..2382713 | - | 306 | WP_001326990.1 | protein YdfV | - |
| CPH39_RS11530 (2382738) | 2382738..2382977 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| CPH39_RS11535 (2382977) | 2382977..2383264 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| CPH39_RS11540 (2383336) | 2383336..2383491 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| CPH39_RS11545 (2383708) | 2383708..2383959 | + | 252 | WP_000980994.1 | protein Rem | - |
| CPH39_RS11550 (2384026) | 2384026..2384304 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| CPH39_RS11555 (2384306) | 2384306..2385355 | + | 1050 | WP_087892834.1 | DUF968 domain-containing protein | - |
| CPH39_RS11560 (2385369) | 2385369..2386121 | + | 753 | WP_001047133.1 | antitermination protein | - |
| CPH39_RS11565 (2386296) | 2386296..2386498 | - | 203 | Protein_2273 | cold shock-like protein CspF | - |
| CPH39_RS11570 (2386797) | 2386797..2387012 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| CPH39_RS11575 (2387376) | 2387376..2387546 | - | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| CPH39_RS11580 (2387767) | 2387767..2387982 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2358637..2398605 | 39968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T138984 WP_000323025.1 NZ_CP043542:2382977-2383264 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T138984 NZ_CP043542:2382977-2383264 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT138984 WP_000534858.1 NZ_CP043542:2382738-2382977 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT138984 NZ_CP058315:c1123661-1123284 [Treponema parvum]
ATGAAAGTCATATATCCCGCTATTTTTCACGGAGAAGACGGCGGTTTTTGGGTTGAATTTCCCGACTTGCCCGGCTGCAC
GACACAAGGCGACAGTCAGGCCGAAACATATATAAATGCCGTTGAAGCGATGGAACTGTTTTTGCAAGACGATTATACCG
TCGATACCTTACCCGCCGCATCTGCAGCAAACAAAATAAAACCCGGCAAAGACAGCTTTGTTGTTTTTGTATGTGGCGAA
TATAAAGAAAATGAAAAAGCCGTAAAAAAAACTTTGACTATACCCTTTTGGCTTAACGTTCAGGCGGAAAAAGCGGGCGT
TAATTTCAGCCAGACGCTGCAAGAGGCCCTTTGCAAAAAATTAAACGTTGTAATGTAG
ATGAAAGTCATATATCCCGCTATTTTTCACGGAGAAGACGGCGGTTTTTGGGTTGAATTTCCCGACTTGCCCGGCTGCAC
GACACAAGGCGACAGTCAGGCCGAAACATATATAAATGCCGTTGAAGCGATGGAACTGTTTTTGCAAGACGATTATACCG
TCGATACCTTACCCGCCGCATCTGCAGCAAACAAAATAAAACCCGGCAAAGACAGCTTTGTTGTTTTTGTATGTGGCGAA
TATAAAGAAAATGAAAAAGCCGTAAAAAAAACTTTGACTATACCCTTTTGGCTTAACGTTCAGGCGGAAAAAGCGGGCGT
TAATTTCAGCCAGACGCTGCAAGAGGCCCTTTGCAAAAAATTAAACGTTGTAATGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|