Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3573048..3573848 Replicon chromosome
Accession NZ_CP043539
Organism Escherichia coli O157 strain Al Ain

Toxin (Protein)


Gene name ataT Uniprot ID A0A891SNC1
Locus tag F0L19_RS17820 Protein ID WP_000342448.1
Coordinates 3573321..3573848 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag F0L19_RS17815 Protein ID WP_072608505.1
Coordinates 3573048..3573314 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0L19_RS17795 3568706..3569374 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
F0L19_RS17800 3569367..3570425 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
F0L19_RS17805 3570670..3571524 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
F0L19_RS17810 3571795..3572898 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
F0L19_RS17815 3573048..3573314 + 267 WP_072608505.1 DUF1778 domain-containing protein Antitoxin
F0L19_RS17820 3573321..3573848 + 528 WP_000342448.1 GNAT family N-acetyltransferase Toxin
F0L19_RS17825 3573845..3574228 - 384 WP_000778769.1 aspartate 1-decarboxylase autocleavage activator PanM -
F0L19_RS17830 3574652..3575761 + 1110 WP_001301528.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
F0L19_RS17835 3575809..3576735 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
F0L19_RS17840 3576732..3578009 + 1278 WP_000803797.1 branched chain amino acid ABC transporter permease LivM -
F0L19_RS17845 3578006..3578773 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19692.68 Da        Isoelectric Point: 7.3232

>T138958 WP_000342448.1 NZ_CP043539:3573321-3573848 [Escherichia coli O157]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

>T138958 NZ_CP043539:3573321-3573848 [Escherichia coli O157]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9852.28 Da        Isoelectric Point: 10.4747

>AT138958 WP_072608505.1 NZ_CP043539:3573048-3573314 [Escherichia coli O157]
MSAVKKQRIDLRLTDGDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT138958 NZ_CP058308:c2753887-2753821 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6GTS

Antitoxin

Source ID Structure

References