Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1423812..1424517 Replicon chromosome
Accession NZ_CP043539
Organism Escherichia coli O157 strain Al Ain

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag F0L19_RS07715 Protein ID WP_000539519.1
Coordinates 1423812..1424198 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F0L19_RS07720 Protein ID WP_001280945.1
Coordinates 1424188..1424517 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0L19_RS07695 1419816..1420442 + 627 WP_001295292.1 glutathione S-transferase GstB -
F0L19_RS07700 1420439..1421554 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
F0L19_RS07705 1421665..1422048 - 384 WP_000497137.1 biofilm formation regulator BssR -
F0L19_RS07710 1422261..1423586 + 1326 WP_149888723.1 30S ribosomal protein S12 methylthiotransferase RimO -
F0L19_RS07715 1423812..1424198 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0L19_RS07720 1424188..1424517 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
F0L19_RS07725 1424587..1425915 - 1329 WP_000086905.1 GGDEF domain-containing protein -
F0L19_RS07730 1425923..1428271 - 2349 WP_000950320.1 EAL domain-containing protein -
F0L19_RS07735 1428449..1429360 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T138947 WP_000539519.1 NZ_CP043539:1423812-1424198 [Escherichia coli O157]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T138947 NZ_CP058308:c595028-594564 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT138947 WP_001280945.1 NZ_CP043539:1424188-1424517 [Escherichia coli O157]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT138947 NZ_CP043539:1424188-1424517 [Escherichia coli O157]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References