Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1300780..1301575 Replicon chromosome
Accession NZ_CP043539
Organism Escherichia coli O157 strain Al Ain

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag F0L19_RS06995 Protein ID WP_000854914.1
Coordinates 1300780..1301154 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag F0L19_RS07000 Protein ID WP_001280954.1
Coordinates 1301201..1301575 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0L19_RS06965 1297458..1298162 + 705 WP_001241680.1 leucyl/phenylalanyl-tRNA--protein transferase -
F0L19_RS06970 1298447..1298665 + 219 WP_001040187.1 translation initiation factor IF-1 -
F0L19_RS06980 1299156..1299998 - 843 WP_001280481.1 DUF4942 domain-containing protein -
F0L19_RS06985 1300083..1300280 - 198 WP_000839282.1 DUF957 domain-containing protein -
F0L19_RS06990 1300292..1300783 - 492 WP_000976853.1 hypothetical protein -
F0L19_RS06995 1300780..1301154 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
F0L19_RS07000 1301201..1301575 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
F0L19_RS07005 1301738..1301959 - 222 WP_001220314.1 DUF987 domain-containing protein -
F0L19_RS07010 1302022..1302498 - 477 WP_001186738.1 RadC family protein -
F0L19_RS07015 1302514..1302999 - 486 WP_000214398.1 antirestriction protein -
F0L19_RS07020 1303090..1303908 - 819 WP_001234682.1 DUF945 domain-containing protein -
F0L19_RS07030 1304248..1305318 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
F0L19_RS07035 1305315..1306220 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T138946 WP_000854914.1 NZ_CP043539:c1301154-1300780 [Escherichia coli O157]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T138946 NZ_CP058308:289207-289734 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT138946 WP_001280954.1 NZ_CP043539:c1301575-1301201 [Escherichia coli O157]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT138946 NZ_CP058308:288934-289200 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References