Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1188035..1188513 Replicon chromosome
Accession NZ_CP043539
Organism Escherichia coli O157 strain Al Ain

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag F0L19_RS06485 Protein ID WP_001303876.1
Coordinates 1188226..1188513 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag F0L19_RS06480 Protein ID WP_000536233.1
Coordinates 1188035..1188226 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0L19_RS06445 1183439..1184209 - 771 WP_000450992.1 DUF1627 domain-containing protein -
F0L19_RS06450 1184231..1184977 - 747 WP_000788751.1 ATP-binding protein -
F0L19_RS06455 1184984..1186075 - 1092 WP_001205823.1 hypothetical protein -
F0L19_RS06460 1186154..1186609 + 456 WP_000273724.1 hypothetical protein -
F0L19_RS06465 1186816..1187241 - 426 WP_000693855.1 Rha family transcriptional regulator -
F0L19_RS06470 1187225..1187497 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
F0L19_RS06475 1187606..1188007 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
F0L19_RS06480 1188035..1188226 + 192 WP_000536233.1 hypothetical protein Antitoxin
F0L19_RS06485 1188226..1188513 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0L19_RS06495 1188791..1188946 + 156 WP_000379575.1 DUF1391 family protein -
F0L19_RS06500 1189088..1189477 + 390 WP_000394511.1 hypothetical protein -
F0L19_RS06505 1189664..1189849 - 186 WP_001133046.1 hypothetical protein -
F0L19_RS06515 1190423..1190611 + 189 WP_000413705.1 cell division inhibition protein DicB -
F0L19_RS06520 1190608..1190799 + 192 WP_001098307.1 DUF1482 family protein -
F0L19_RS06525 1190893..1193364 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T138945 WP_001303876.1 NZ_CP043539:1188226-1188513 [Escherichia coli O157]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T138945 NZ_CP043539:1188226-1188513 [Escherichia coli O157]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT138945 WP_000536233.1 NZ_CP043539:1188035-1188226 [Escherichia coli O157]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT138945 NZ_CP058307:c1565220-1564960 [Avibacterium paragallinarum]
ATGGCAATTCAGCAAATTTTAACCCGCCACACGGCAAGCATTAGCGACTTGAAAAAAAATCCTATGGGGATTGTATCAGA
GGGAACAGAGCAAGAAGGGGCGATCGCTATTCTAAACCGTAATGAACCCGTGTTTTATTGCGTAAATCCCTGTCTTTTTG
CGGTTATTCAAGAAATCCTTGAAGACAAAGAACTAGGCGAACTCGCCACACAACGCCTTGCAACCCTTGACCCCGTCGAG
GTGCGTTTAGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References