Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 5247973..5248562 Replicon chromosome
Accession NZ_CP043538
Organism Methylobacterium mesophilicum SR1.6/6

Toxin (Protein)


Gene name PumA Uniprot ID A0A6B9FV89
Locus tag MMSR116_RS24845 Protein ID WP_010685564.1
Coordinates 5247973..5248263 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A6B9FSW0
Locus tag MMSR116_RS24850 Protein ID WP_010685565.1
Coordinates 5248266..5248562 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMSR116_RS24815 5243129..5243542 + 414 WP_010685558.1 DUF1236 domain-containing protein -
MMSR116_RS24820 5243688..5243960 + 273 WP_010685559.1 hypothetical protein -
MMSR116_RS24825 5243965..5244384 - 420 WP_010685560.1 large conductance mechanosensitive channel protein MscL -
MMSR116_RS24830 5244581..5245468 - 888 WP_010685561.1 phosphatidylcholine/phosphatidylserine synthase -
MMSR116_RS24835 5245477..5246187 - 711 WP_010685562.1 phosphatidylserine decarboxylase -
MMSR116_RS24840 5247000..5247905 + 906 WP_010685563.1 NAD(P)-dependent oxidoreductase -
MMSR116_RS24845 5247973..5248263 + 291 WP_010685564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MMSR116_RS24850 5248266..5248562 + 297 WP_010685565.1 putative addiction module antidote protein Antitoxin
MMSR116_RS24855 5248582..5250504 - 1923 WP_010685566.1 ABC transporter ATP-binding protein/permease -
MMSR116_RS24860 5250592..5250813 - 222 WP_039894042.1 translation initiation factor IF-2 -
MMSR116_RS24865 5250918..5252252 + 1335 WP_010685567.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10808.38 Da        Isoelectric Point: 10.4973

>T138929 WP_010685564.1 NZ_CP043538:5247973-5248263 [Methylobacterium mesophilicum SR1.6/6]
VPLLRRTPTYQSWIDGLRDRRAATRVLARVARLGLGNPGDVRPVGEGVRELRIDYGPGYRVYDVQHGEEIVILLCGGDKG
SRNRDIREAKRLAKDL

Download         Length: 291 bp

>T138929 NZ_CP058302:c4388920-4388813 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10746.31 Da        Isoelectric Point: 4.6768

>AT138929 WP_010685565.1 NZ_CP043538:5248266-5248562 [Methylobacterium mesophilicum SR1.6/6]
MPLETRPYDTAEHLRTPEDIVLHIEAVLEDGDPALVADAIGVVARARGMAQIAQETGRSREQLYRTLSEKGNPQLDTLMG
VLKAIGLRLSVKPIETEV

Download         Length: 297 bp

>AT138929 NZ_CP058302:4388967-4389033 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B9FV89

Antitoxin

Source ID Structure
AlphaFold DB A0A6B9FSW0

References