Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 1630223..1631329 Replicon chromosome
Accession NZ_CP043511
Organism Enterobacter kobei strain EB_P8_L5_01.19

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FZO55_RS07925 Protein ID WP_058691085.1
Coordinates 1630799..1631329 (-) Length 177 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FZO55_RS07920 Protein ID WP_058691086.1
Coordinates 1630223..1630660 (-) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZO55_RS07905 1626447..1627445 + 999 WP_014884564.1 galactose/glucose ABC transporter substrate-binding protein MglB -
FZO55_RS07910 1627525..1629045 + 1521 WP_014884563.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
FZO55_RS26170 1629061..1629192 + 132 Protein_1508 beta-methylgalactoside transporter permease -
FZO55_RS07915 1629283..1630185 + 903 Protein_1509 galactose/methyl galactoside ABC transporter permease MglC -
FZO55_RS07920 1630223..1630660 - 438 WP_058691086.1 helix-turn-helix domain-containing protein Antitoxin
FZO55_RS07925 1630799..1631329 - 531 WP_058691085.1 hypothetical protein Toxin
FZO55_RS07930 1631461..1632174 - 714 WP_032636024.1 outer membrane permeability protein SanA -
FZO55_RS07935 1632302..1633186 - 885 WP_014884560.1 cytidine deaminase -
FZO55_RS07940 1633316..1634011 - 696 WP_014884559.1 CidB/LrgB family autolysis modulator -
FZO55_RS07945 1634008..1634403 - 396 WP_058691084.1 CidA/LrgA family protein -
FZO55_RS07950 1634572..1635504 + 933 WP_023330920.1 tRNA dihydrouridine(16) synthase DusC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19575.80 Da        Isoelectric Point: 4.1958

>T138909 WP_058691085.1 NZ_CP043511:c1631329-1630799 [Enterobacter kobei]
METLTVQAYLHEVWTDIALITFPGSENNDWNTTQLNYRTEYAINFLDYDDLHAVTLNHPVSLFFNDHGNPGWLRFIDDII
PAGASRRYWINALGISELPLSQQNFLLLKFGTMSPVGNLRIKESVPEWNEFASAKTFTVTDVIERAADFLDYAQERGAAA
GGATGAGGVDSPFDVA

Download         Length: 531 bp

>T138909 NZ_CP058287:c557372-557091 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTGCAAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16377.73 Da        Isoelectric Point: 10.4647

>AT138909 WP_058691086.1 NZ_CP043511:c1630660-1630223 [Enterobacter kobei]
MKIPDKTESEFLQTLARIRSANGRRHHDDAEDPDKLTQVNRQRVSPSLTRVDTRDRQDLLHAAIRDILLGKITQGEALRK
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFS

Download         Length: 438 bp

>AT138909 NZ_CP058287:c557679-557365 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAACAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTGAATACGATCGCCTCAAAAGATGACCCAAAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAGACAAGAAAGAGAAAGGCGTAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References