Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 896283..896940 Replicon chromosome
Accession NZ_CP043511
Organism Enterobacter kobei strain EB_P8_L5_01.19

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag FZO55_RS04400 Protein ID WP_014885136.1
Coordinates 896530..896940 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag FZO55_RS04395 Protein ID WP_010435322.1
Coordinates 896283..896549 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZO55_RS04375 891717..893150 - 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -
FZO55_RS04380 893267..893998 - 732 WP_058689873.1 MurR/RpiR family transcriptional regulator -
FZO55_RS04385 894264..894923 + 660 WP_023331242.1 hemolysin III family protein -
FZO55_RS04390 895008..895988 - 981 WP_014885137.1 tRNA-modifying protein YgfZ -
FZO55_RS04395 896283..896549 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
FZO55_RS04400 896530..896940 + 411 WP_014885136.1 protein YgfX Toxin
FZO55_RS04405 896946..897467 - 522 WP_014885135.1 flavodoxin FldB -
FZO55_RS04410 897569..898465 + 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
FZO55_RS04415 898494..899207 + 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FZO55_RS04420 899213..900946 + 1734 WP_023331239.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T138908 WP_014885136.1 NZ_CP043511:896530-896940 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T138908 NZ_CP058285:c910667-910401 [Helicobacter pylori]
GTGTTGAAGCTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAAGAAGTCATTCTGACCTTGAGAAAGAAAGAACCGCTACCCCCACCATTTAAAGATCACGCTTTAAAGGGGGTTTGGA
AGCCTTATAGAGAATGCCATATCAAAGCTGATGTTTTGCTTGTGTGTTTAGTGAAAGGTGATGAGCTGATTTTATTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT138908 WP_010435322.1 NZ_CP043511:896283-896549 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138908 NZ_CP058285:c911025-910648 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAATCTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
GGGCATGAAACCCCAAACATTCAAACGCAACAAGCCATGAGAGAAGCGGATAACAAAGAAACAGATTTGTTCGTTGAGGA
TTTTTCTAGCTATAGCAATGAAAGAAAAAAGGCTTTAGGTGTTGAAGCTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References