Detailed information of TA system TA138906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 94303..94931
• Replicon: plasmid unnamed2
• Accession: NZ_CP043508
• Organism: Acetobacter sp. KACC 21233

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FLP30_RS13990
• Protein ID: WP_149280611.1
• Coordinates: 94527..94931 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FLP30_RS13985
• Protein ID: WP_149280610.1
• Coordinates: 94303..94527 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FLP30_RS13950	89321..90334	-	1014	WP_149280604.1	plasmid replication protein	-
FLP30_RS13955	90794..90910	+	117	WP_149280605.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FLP30_RS13960	91057..92058	+	1002	WP_149280606.1	tyrosine-type recombinase/integrase	-
FLP30_RS13965	92055..92756	+	702	WP_149280607.1	hypothetical protein	-
FLP30_RS13970	92756..93487	+	732	WP_149280608.1	hypothetical protein	-
FLP30_RS13975	93646..93888	+	243	WP_149280609.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FLP30_RS13985	94303..94527	+	225	WP_149280610.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FLP30_RS13990	94527..94931	+	405	WP_149280611.1	tRNA(fMet)-specific endonuclease VapC	Toxin
FLP30_RS13995	94975..95208	-	234	Protein_101	transposase	-
FLP30_RS14000	95194..95826	+	633	Protein_102	IS5 family transposase	-
FLP30_RS14005	96189..98387	+	2199	WP_149280612.1	methyl-accepting chemotaxis protein	-
FLP30_RS14010	98690..99200	-	511	Protein_104	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..102624	102624
	-	flank	IS/Tn	-	-	95074..95826	752

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15079.14 Da
• Isoelectric Point: 6.4750

>T138906 WP_149280611.1 NZ_CP043508:94527-94931 [Acetobacter sp. KACC 21233]
MLRYLLDTNFCIRVLRDRPQGLRERFNDNAEALCISDVVLYELLYGAEKAQNAAKTRREVEHFAARLSVLPFDDAAAAHT
AEIRADLERHGCTIGPYDLMIAGHARSNGLIVVTGNLREFTRVTGLRCEDWTAS

Nucleotide

• Length: 405 bp

>T138906 NZ_CP043508:94527-94931 [Acetobacter sp. KACC 21233]
ATGCTACGTTACTTGCTGGATACAAACTTCTGCATCCGTGTTCTACGCGATCGTCCTCAAGGCCTACGAGAACGTTTCAA
TGATAACGCTGAGGCTCTCTGTATCTCAGATGTCGTATTATACGAACTGCTCTATGGTGCTGAGAAAGCCCAGAACGCTG
CCAAAACCCGTCGTGAAGTCGAGCACTTCGCCGCGCGCCTGTCTGTCCTGCCGTTTGATGACGCAGCAGCAGCCCACACT
GCCGAGATAAGGGCCGATCTCGAGCGACATGGCTGCACAATCGGCCCCTATGATCTCATGATTGCTGGCCATGCTCGGAG
CAACGGCCTTATTGTCGTAACCGGAAACCTACGCGAGTTTACCAGAGTGACGGGTCTCCGCTGTGAAGACTGGACGGCTA
GTTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8188.37 Da
• Isoelectric Point: 6.2357

>AT138906 WP_149280610.1 NZ_CP043508:94303-94527 [Acetobacter sp. KACC 21233]
MLTRTTLFLSNRSQAVRLPKAVAFDSPLKDVVIIPDGARRIIAPADAGWDDFFAAAGTNLPERIQPSMQERESF

Nucleotide

• Length: 225 bp

>AT138906 NZ_CP058281:c1545191-1544754 [Helicobacter pylori]
ATGGTCAATACTTTGGAACTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGAGAAGTGTATTATGAATATCGCAATTACGGTGCCAATTCTATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAGTCTTAGAGAAGATGAACTTGAAGCCATCAATCGCTCCATAAAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAACTAA