Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 135219..135802 Replicon plasmid unnamed1
Accession NZ_CP043507
Organism Acetobacter sp. KACC 21233

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FLP30_RS13310 Protein ID WP_081477885.1
Coordinates 135458..135802 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FLP30_RS13305 Protein ID WP_149280497.1
Coordinates 135219..135461 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLP30_RS13290 130561..131376 + 816 WP_149280494.1 hypothetical protein -
FLP30_RS13295 131752..133242 + 1491 WP_168200140.1 TIR domain-containing protein -
FLP30_RS13300 133521..134912 - 1392 WP_149280496.1 site-specific integrase -
FLP30_RS13305 135219..135461 + 243 WP_149280497.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FLP30_RS13310 135458..135802 + 345 WP_081477885.1 endoribonuclease MazF Toxin
FLP30_RS13315 136001..137083 - 1083 Protein_133 IS5 family transposase -
FLP30_RS13325 137343..137654 - 312 WP_149280499.1 hypothetical protein -
FLP30_RS13330 137723..138535 - 813 WP_149280500.1 hypothetical protein -
FLP30_RS13335 138594..139226 - 633 WP_149280501.1 hypothetical protein -
FLP30_RS13340 139219..140523 - 1305 WP_149280502.1 replicator initiator RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..165009 165009
- flank IS/Tn - - 136622..137080 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(13-112)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12546.75 Da        Isoelectric Point: 10.1798

>T138905 WP_081477885.1 NZ_CP043507:135458-135802 [Acetobacter sp. KACC 21233]
VSAKVKTAWVPDCGDIVWLEFDPQAGREQAGHRPAVVLSPASYNAKAGMMLCCPTTTKIKGYPFEVALTGKTASVVLSDQ
LRSLDWRVRKAKLKGKVLPEELEAIRQRIRLLLG

Download         Length: 345 bp

>T138905 NZ_CP043507:135458-135802 [Acetobacter sp. KACC 21233]
GTGAGTGCCAAAGTAAAGACTGCTTGGGTTCCTGATTGCGGGGACATCGTTTGGCTGGAATTTGATCCGCAGGCGGGCAG
GGAGCAGGCAGGACACCGGCCTGCTGTTGTGTTGAGCCCCGCCAGTTATAACGCTAAAGCTGGAATGATGCTGTGCTGTC
CGACAACGACCAAAATCAAAGGCTACCCCTTTGAAGTGGCTCTGACTGGAAAAACTGCCAGTGTGGTTTTGTCAGATCAG
CTCAGAAGTCTGGATTGGCGCGTGAGAAAGGCAAAGCTCAAAGGCAAAGTTTTACCAGAAGAGCTTGAGGCCATCCGGCA
GCGTATCAGATTGCTGCTTGGGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8741.00 Da        Isoelectric Point: 4.4488

>AT138905 WP_149280497.1 NZ_CP043507:135219-135461 [Acetobacter sp. KACC 21233]
MQGVVRKWGNSAAIRLPAGVLEAVSLKIDQAVDVREEDGRIIIEPVKAVPLKLEELVSGITAENRHDEMDFGPFVGGESW

Download         Length: 243 bp

>AT138905 NZ_CP043507:135219-135461 [Acetobacter sp. KACC 21233]
ATGCAAGGCGTTGTCAGGAAATGGGGAAACAGTGCAGCCATTCGTCTTCCCGCTGGTGTGCTTGAAGCCGTCAGTCTGAA
GATCGATCAGGCCGTCGATGTGCGGGAAGAAGATGGACGGATTATCATTGAGCCAGTCAAAGCAGTTCCTCTCAAACTGG
AAGAATTAGTGTCAGGTATTACGGCCGAGAACCGCCATGATGAAATGGACTTTGGTCCGTTTGTGGGTGGTGAAAGCTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References