Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2335549..2336129 Replicon chromosome
Accession NZ_CP043504
Organism Protaetiibacter larvae strain KACC 19322

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FLP23_RS11020 Protein ID WP_149325906.1
Coordinates 2335549..2335914 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FLP23_RS11025 Protein ID WP_149325907.1
Coordinates 2335911..2336129 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLP23_RS10995 2331746..2332711 - 966 WP_149325901.1 hypothetical protein -
FLP23_RS11000 2332918..2333781 + 864 WP_149325902.1 hypothetical protein -
FLP23_RS11005 2333955..2334221 + 267 WP_149325903.1 PilZ domain-containing protein -
FLP23_RS11010 2334232..2334462 - 231 WP_149325904.1 helix-turn-helix transcriptional regulator -
FLP23_RS12315 2334606..2335121 + 516 WP_168200432.1 hypothetical protein -
FLP23_RS12320 2335108..2335545 + 438 WP_168200433.1 HNH endonuclease family protein -
FLP23_RS11020 2335549..2335914 - 366 WP_149325906.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FLP23_RS11025 2335911..2336129 - 219 WP_149325907.1 ribbon-helix-helix protein, CopG family Antitoxin
FLP23_RS11030 2336325..2336783 + 459 WP_149325908.1 DUF1801 domain-containing protein -
FLP23_RS11035 2336785..2338086 - 1302 WP_149325909.1 CDP-glycerol glycerophosphotransferase family protein -
FLP23_RS11040 2338143..2339381 + 1239 Protein_2168 CDP-glycerol glycerophosphotransferase family protein -
FLP23_RS11045 2339445..2340938 + 1494 WP_149326294.1 CDP-glycerol glycerophosphotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 12827.91 Da        Isoelectric Point: 9.0329

>T138902 WP_149325906.1 NZ_CP043504:c2335914-2335549 [Protaetiibacter larvae]
VTDGLVVRRGAVVLVLLDPAVGSEQGKTRPAVVVSTDAANAAALFHQRGVVTVVPVTSNVERILPIHVLLPRADTGLPIE
SKAQPEQVRAVDVTRVVRSFNVLRGETMAAVDEALRLHLGL

Download         Length: 366 bp

>T138902 NZ_CP058277:c460688-460242 [Mycobacterium marinum]
ATGGCGAAACTTTCCGGGTCGATCGACGTGCCGCTGTCTCCGGACGAGGCATGGATGCACGCATCCGATCTCTCCCGCTT
CAAGGAGTGGCTGACGATCCACCGAGTGTGGCGCAGCACGTTGCCCGAAACCCTCGAAAAGGGTGCGGTCGTCGAATCAA
TCGTGCAGGTCAAGGGCATGCACAACCGCATCAAATGGACCATCGTGCGCTACCAGCCGCCGGAAGGCATGACCCTCAAC
GGTGACGGGGTCGGCGGCGTCAAGGTCAAGCTGATGGCCAAGGTTGCAGCCGGAGAAGAAGGCTCGATCGTCAGCTTCGA
CGTGCACCTTGGTGGGCCGGCTCTGTTCGGTCCGATCGGCATGGTCGTCGCCGCGGCGCTGCGCAGCGATATCAACGCAT
CGCTGCGGAACTTCGTCACCGTATTCGCCCCGTCGGCTGCCGGCTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7603.41 Da        Isoelectric Point: 3.9362

>AT138902 WP_149325907.1 NZ_CP043504:c2336129-2335911 [Protaetiibacter larvae]
MKVSISLSDDDLAFLDAETASGAFPSRSAAVAAAIRALRNRDLVAVYADAFLEWSDTEEADAWGAVLRDGVA

Download         Length: 219 bp

>AT138902 NZ_CP058277:c460881-460693 [Mycobacterium marinum]
ATGGGAATCCTGGACAAGGCGAAAGACCTGCTGGCGCAGAACGCCGACAAGGTCGAGACGGTGATCGACAAGGCCGGCGA
ATTCGTCGACGAGAAGACCGAGGGGAAGTACTCCGACACCATCCACAAGGTGCAAGAGGGGGCCAAGAAAGTCGCTGGTC
CCGGCGCCGCGGGCGAGCAGCAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References