Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1469620..1470276 Replicon chromosome
Accession NZ_CP043504
Organism Protaetiibacter larvae strain KACC 19322

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FLP23_RS06955 Protein ID WP_149325183.1
Coordinates 1469620..1470012 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FLP23_RS06960 Protein ID WP_149325184.1
Coordinates 1470013..1470276 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLP23_RS06925 1464978..1465172 + 195 WP_149325177.1 hypothetical protein -
FLP23_RS06930 1465268..1466422 + 1155 WP_149325178.1 agmatine deiminase family protein -
FLP23_RS06935 1466529..1468217 + 1689 WP_149325179.1 amidase -
FLP23_RS06940 1468292..1468789 + 498 WP_149325180.1 CrcB family protein -
FLP23_RS06945 1468786..1469163 + 378 WP_149325181.1 fluoride efflux transporter CrcB -
FLP23_RS06950 1469223..1469507 + 285 WP_149325182.1 hypothetical protein -
FLP23_RS06955 1469620..1470012 - 393 WP_149325183.1 type II toxin-antitoxin system VapC family toxin Toxin
FLP23_RS06960 1470013..1470276 - 264 WP_149325184.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FLP23_RS06965 1470386..1472119 - 1734 WP_149325185.1 DUF2075 domain-containing protein -
FLP23_RS06970 1472106..1472426 - 321 WP_149325186.1 nucleotide pyrophosphohydrolase -
FLP23_RS06975 1472574..1473503 - 930 WP_168200396.1 NERD domain-containing protein -
FLP23_RS06980 1473562..1474338 + 777 WP_149325188.1 NERD domain-containing protein -
FLP23_RS06985 1474452..1474682 - 231 WP_149325189.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-80)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14334.41 Da        Isoelectric Point: 4.6617

>T138900 WP_149325183.1 NZ_CP043504:c1470012-1469620 [Protaetiibacter larvae]
VFSYLDTSALVKLVVAEAETDALIAWVEQRHDHLATSLLARAELQRAVRRTAPDLLERAREVLGTLHLLGMPSVGYDEAA
RLEPAALRTLDALHLASALRLEEQLEAIISYDERLNDAARLLGITVLSPE

Download         Length: 393 bp

>T138900 NZ_CP058272:291880-292236 [Acinetobacter sp. MYb10]
ATGTGGACAGTCATTACAACGGATTTGTTTAATGAATGGCTTGAACAGCAAGATGATTCAACACAGGAAAAAGTCTTAGC
TGCATTGGTCGTTCTACAACAGCTGGGGCCAAGTTTAGGTCGCCCTTTAGTTGATACCGTAAATGACTCGAAATTCACGA
ACATGAAAGAATTACGTGTTCAGCATAGAGGTAAACCACTAAGAGCCTTTTTTATATTTGATCCATTACGACAGGCTATT
GTGCTTTGTATTGGTAATAAGGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCAGAACAGCAATACGAACT
TCATCTTTCAACCCTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9179.44 Da        Isoelectric Point: 6.2995

>AT138900 WP_149325184.1 NZ_CP043504:c1470276-1470013 [Protaetiibacter larvae]
MEQIGIRALKQNASAVVARVAAGESLVITDRGRAVAQLVPLPATPIERMLADGTASAPARDIRTLSAPAAGPDLSASLRE
QRDEERY

Download         Length: 264 bp

>AT138900 NZ_CP043504:c1470276-1470013 [Protaetiibacter larvae]
ATGGAGCAGATCGGCATCCGAGCGCTCAAGCAGAACGCATCGGCGGTGGTCGCACGAGTCGCCGCCGGGGAGTCGCTCGT
GATCACGGATCGCGGCCGGGCCGTCGCGCAGCTCGTACCGCTGCCCGCCACCCCGATCGAGCGGATGCTCGCCGACGGCA
CAGCATCCGCTCCCGCGCGCGACATCCGCACGCTGTCGGCGCCCGCAGCGGGGCCCGACCTCAGCGCGAGCCTCCGCGAG
CAGCGCGACGAGGAACGGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References