Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-KacA/DUF1778(antitoxin)
Location 298693..299486 Replicon chromosome
Accession NZ_CP043504
Organism Protaetiibacter larvae strain KACC 19322

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag FLP23_RS01360 Protein ID WP_149324216.1
Coordinates 298693..299214 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag FLP23_RS01365 Protein ID WP_149324217.1
Coordinates 299211..299486 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLP23_RS01320 294110..294535 - 426 WP_149324209.1 MaoC family dehydratase N-terminal domain-containing protein -
FLP23_RS01325 294532..294978 - 447 WP_149324210.1 MaoC family dehydratase N-terminal domain-containing protein -
FLP23_RS01335 295180..295785 - 606 WP_149324211.1 response regulator transcription factor -
FLP23_RS01340 295795..296445 - 651 WP_149324212.1 NAD(P)H-dependent oxidoreductase -
FLP23_RS01345 296524..296970 + 447 WP_149324213.1 MarR family transcriptional regulator -
FLP23_RS01350 297105..297836 + 732 WP_149324214.1 ATP-binding cassette domain-containing protein -
FLP23_RS01355 297863..298678 + 816 WP_149324215.1 hypothetical protein -
FLP23_RS01360 298693..299214 - 522 WP_149324216.1 GNAT family N-acetyltransferase Toxin
FLP23_RS01365 299211..299486 - 276 WP_149324217.1 DUF1778 domain-containing protein Antitoxin
FLP23_RS01370 299606..300838 - 1233 WP_149324218.1 IS481 family transposase -
FLP23_RS01385 301179..303080 - 1902 WP_149324219.1 glycoside hydrolase family 13 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-151)

Antitoxin

Vibrio phage ICP1, Orf50

(9-85)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 18347.76 Da        Isoelectric Point: 6.9791

>T138899 WP_149324216.1 NZ_CP043504:c299214-298693 [Protaetiibacter larvae]
MTSFARPRSLALDDEVSAFHSGVPSLDDWLTLRAIKNEAAGTSRTFVSIERESGRIAGYYCLSSSSISRVDAGSPLGRNA
PDPIPVILIGRLAVDERFTGQGVGASLLQDAVLKGIEASHLVGSRAFLVHALSEAAASFYARFGFAAVPHSQRVMYLLTH
DAEATIAGITTRG

Download         Length: 522 bp

>T138899 NZ_CP058262:200873-201223 [Priestia megaterium]
TTGGTAGTCAAACGTGGCGACGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGAGGCGTTCGCCCTGT
ACTTGTCATTCAAAATGATATAGGCAATCGTTTTAGCCCAACTGTTATTGTAGCTGCGATCACTGCTCAAATTCAAAAGG
CAAAGTTACCTACGCATGTTGAAATTGATGCAAAGCGCTATGGATTTGAGCGAGATTCAGTTATTTTACTAGAACAAATT
CGTACTATTGATAAACAGAGGCTAACAGACAAGATTACCCATTTAGATGATGAAATGATGGACAGAGTGGATGAAGCCTT
GCAAATCAGTGTAGGACTTATCGACTTTTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10232.63 Da        Isoelectric Point: 5.1667

>AT138899 WP_149324217.1 NZ_CP043504:c299486-299211 [Protaetiibacter larvae]
MASALKNDRLELRLTAQQKRTIEQAATISGQSVTEFSVPRLVEEATEVIRQERELHMSAEAWEAFNAVLDRPAAPVARLA
ELLRRPSVFTD

Download         Length: 276 bp

>AT138899 NZ_CP043504:c299486-299211 [Protaetiibacter larvae]
ATGGCCTCCGCACTCAAGAACGATCGCCTCGAGCTGCGGCTGACCGCCCAACAGAAGCGGACCATCGAACAGGCGGCGAC
GATCTCGGGTCAGTCGGTGACCGAGTTCTCGGTACCGCGGCTGGTGGAGGAGGCGACCGAGGTCATCAGGCAGGAACGCG
AGCTGCACATGTCCGCGGAAGCCTGGGAGGCGTTCAACGCCGTCCTCGACCGTCCGGCGGCACCGGTCGCCCGATTGGCC
GAGCTTCTGCGTCGGCCCTCGGTGTTCACGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References